US2004186050A1PendingUtilityA1

Method for orally administering parathyroid hormone (pth)

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Priority: Jun 1, 2001Filed: May 31, 2002Published: Sep 23, 2004
Est. expiryJun 1, 2021(expired)· nominal 20-yr term from priority
Inventors:Joseph AultMoise AzriaSimon David BatemanJames Mcleod
A61P 43/00A61P 5/18A61P 19/00A61K 47/183A61K 38/29A61P 19/10A61K 38/23A61P 19/08A61P 19/02
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Claims

Abstract

A method for orally administering a parathyroid hormone, PTH, comprising orally co-administering to a patient in need of PTH an effective amount of a PTH and an effective amount of a calcitonin. The method according to the invention allows for the oral administration of PTH without the hypercalcemia, hypercalcuria and nephrolithiasis side effects.

Claims

exact text as granted — not AI-modified
We claim:  
     
         1 . A method for orally administering an effective dose of PTH comprising orally co-administering to a patient in need of PTH an effective amount of a PTH and an effective amount of a calcitonin.  
     
     
         2 . A method according to  claim 1  wherein the calcitonin is salmon calcitonin.  
     
     
         3 . A method of stimulating new bone formation comprising orally administering to a patient in need of new bone formation a therapeutically effective amount of a PTH and a therapeutically effective amount of a calcitonin.  
     
     
         4 . A method according to  claim 3  wherein the calcitonin is salmon calcitonin.  
     
     
         5 . A method of treatment or prevention of osteoporosis comprising orally administering to a patient in need of said treatment or prevention a therapeutically effective amount of a PTH and a therapeutically effective amount of a calcitonin.  
     
     
         6 . A method according to  claim 5  wherein said calcitonin is salmon calcitonin.  
     
     
         7 . A composition for oral administration comprising a PTH and a calcitonin.  
     
     
         8 . A composition according to  claim 7  wherein the PTH is a human form of PTH.  
     
     
         9 . A compostion according to  claim 8  wherein the calcitonin is salmon calcitonin.  
     
     
         10 . Use of PTH and calcitonin for the preparation of an orally administrable medicament for the stimulation of bone formation.  
     
     
         11 . Use according to  claim 10  wherein the PTH is a human form of PTH.  
     
     
         12 . Use according to  claim 11  wherein the calcitonin is salmon calcitonin.  
     
     
         13 . A kit for the stimulation of new bone formation comprising PTH and calcitonin suitable for oral administration together with instructions for the oral administration thereof.

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