Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same

Abstract

A neuroprotectant composition wherein the active ingredient is pGLU-GLU-PRO-NH 2 or a combination of pGLU-GLU-PRO-NH 2 (EEP) and N-tert-Butyl-α-(2-sulfophenyl)nitrone (SPBN) or other nitrone. A method of treating and preventing diseases and injuries of the brain, spinal cord and retina is also presented by administering the endogenous tripeptide EEP to a subject as a neuroprotectant or by administering EEP in combination with SPBN or other nitrone.

1 - 12 . (canceled).  
     
     
         13 . A pharmaceutical composition comprising a neuroprotective amount of pGLU-GLU-PRO-amide as an active ingredient and a pharmaceutically acceptable carrier, wherein said neuroprotective amount is an amount of 4.0 mg/kg to about 10 mg/kg to reduce Glu induced neurotoxicity in brain, spinal cord and/or retina.  
     
     
         14 . The composition of  claim 13 , wherein said pharmaceutically acceptable carrier is one or more ingredients selected from the group consisting of: starch, sugar, flavoring agents, preservatives, water, organic co-solvents, flavor emulsions, oils and elixirs.  
     
     
         15 . The composition of  claim 13 , wherein said pharmaceutically acceptable carrier affords prolonged action or sustained release.