Dual chamber dissolution container with passive agitation

Abstract

A reagent dissolution device and methods of using the same, wherein the device comprises a housing ( 40 ), a diluent ( 25 ), and at least one reagent bed ( 35 ), wherein the diluent ( 25 ) and the at least one reagent bed ( 35 ) are separated by a friable barrier ( 50 ) and a flow distribution disk ( 100 ). Alternate embodiments include chambers with a plurality of reagent beds as well as chambers for the mixing of two or more liquid reagents.

What is claimed is:  
     
         1 . A reagent dissolution device comprising a housing, a diluent, and at least one reagent bed, wherein the diluent and the at least one reagent bed are separated by a friable barrier and a flow distribution disk.  
     
     
         2 . The reagent dissolution device of  claim 1 , further comprising a porous expansion component located between the friable barrier and the flow distribution disk.  
     
     
         3 . The reagent dissolution device of  claim 1 , wherein the flow distribution disk contains a plurality of directional channels disposed at a range from 30 to 90 degrees with respect to the vertical axis of the disk.  
     
     
         4 . The reagent dissolution device of  claim 1 , wherein the flow distribution disk contains a plurality of directional channels disposed at a range from 45 to 75 degrees with respect to the vertical axis of the disk.  
     
     
         5 . The reagent dissolution device of  claim 1 , wherein the flow distribution disk contains a plurality of directional channels disposed at a range from 55 to 65 degrees with respect to the vertical axis of the disk.  
     
     
         6 . The reagent dissolution device of  claim 1 , wherein the flow distribution disk comprises a top layer and an adjacently disposed bottom layer that form a distribution chamber.  
     
     
         7 . The reagent dissolution device of  claim 6 , wherein the bottom layer is a porous plate.  
     
     
         8 . The reagent dissolution device of  claim 6 , wherein the bottom layer comprises a plurality of directional channels bounded by an inlet port and an outlet port.  
     
     
         9 . The reagent dissolution device of  claim 1 , further comprising a pressure-generating plunger.  
     
     
         10 . The reagent dissolution device of  claim 1 , further comprising a pressure-generating spring.  
     
     
         11 . The reagent dissolution device of  claim 1 , wherein the diluent comprises a first liquid reagent.  
     
     
         12 . The reagent dissolution device of  claim 11 , wherein the at least one reagent bed contains a second liquid reagent.  
     
     
         13 . The reagent dissolution device of  claim 1 , wherein the at lest one reagent bed comprises a dry reagent bed.  
     
     
         14 . A method of preparing a pharmaceutically acceptable solution comprising: 
 providing a dissolution chamber, wherein the dissolution chamber comprises a housing, a diluent, and at least one reagent bed, wherein the diluent and the at least one reagent bed are separated by a friable barrier and a flow distribution disk;    applying sufficient pressure to the diluent such that the friable barrier is ruptured and the diluent is applied to the flow distribution disk, micro-spirals are creating in the diluent emerging from the distribution disk; and    dissolving the at least one reagent bed with the diluent such that the pharmaceutically acceptable solution is prepared.    
     
     
         15 . The method of  claim 14 , wherein mixing comprises dissolving dry reagent from the at least one reagent bed.  
     
     
         16 . The method of  claim 14 , wherein mixing comprises mixing the diluent with liquid reagent from the at least one reagent bed.