Diagnostics and therapeutics for restenosis

Abstract

Methods and kits for determining whether a subject has or is predisposed to developing restenosis are provided.

1 - 7 . (Cancelled)  
     
     
         8 . A kit for determining the existence of or a susceptibility to developing a restenosis in a subject, said kit comprising a first primer oligonucleotide that hybridizes 5′ or 3′ to an allele selected from the group consisting of allele 1 of any of the following markers: IL-1A (+4845), IL-1B (−511), IL-1B (+3954), IL-1RN (VNTR) and IL-1RN (+2018) or an allele in linkage disequilibrium therewith.  
     
     
         9 . The kit of  claim 8 , which additionally comprises a second primer oligonucleotide that hybridizes either 3′ or 5′ respectively to the allele so that the allele can be amplified.  
     
     
         10 . The kit of  claim 9 , wherein said first primer and said second primer hybridize to a region in the range of between about 50 and about 1000 base pairs.  
     
     
         11 . The kit of  claim 8 , wherein said primer is selected from the group consisting of any of SEQ ID Nos. 1-14.  
     
     
         12 . The kit of  claim 8 , which additionally comprises a detection means.  
     
     
         13 . The kit of  claim 12 , wherein the detection means is selected from the group consisting of: 
 a) allele specific oligonucleotide hybridization;    b) size analysis;    c) sequencing;    d) hybridization;    e) 5′ nuclease digestion;    f) single-stranded conformation polymorphism;    g) allele specific hybridization;    h) primer specific extension; and    j) oligonucleotide ligation assay.    
     
     
         14 . The kit of  claim 8 , which additionally comprises an amplification means.  
     
     
         15 . The kit of  claim 8 , which further comprises a control.  
     
     
         16 - 79 . (Cancelled)