US2004234624A1PendingUtilityA1

Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia

Priority: Dec 23, 1998Filed: Jun 10, 2004Published: Nov 25, 2004

Est. expiryDec 23, 2018(expired)· nominal 20-yr term from priority

Inventors:John Mckearn Gary B. Gordon James J. Cunningham Stephen Gately Alane T. Koki Jaime Masferrer

A61K 31/445A61K 33/243A61K 31/135A61K 41/00A61K 31/505A61K 45/06A61K 31/415A61K 41/0038A61K 31/506A61K 31/675A61K 31/42

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Abstract

The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of an integrin antagonist and an antineoplastic agent.

Claims

exact text as granted — not AI-modified

1 - 115 . (cancelled).  
     
     
         116 . A combination comprising an integrin antagonist and tamoxifen in amounts effective, when used in a combination therapy, for treatment of neoplasia or a neoplasia-related disorder.  
     
     
         117 . A method for treating neoplasia or a neoplasia-related disorder in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a combination comprising an integrin antagonist and tamoxifen.  
     
     
         118 . The method of  claim 117  wherein the neoplasia or neoplasia-related disorder is breast cancer.

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