US2004235118A1PendingUtilityA1

Portions of soluble recombinant botulinum toxins

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Assignee: ALLERGAN INC ALLERGAN BOTOX LTPriority: Mar 16, 1995Filed: Dec 4, 2003Published: Nov 25, 2004
Est. expiryMar 16, 2015(expired)· nominal 20-yr term from priority
Inventors:James A. Williams
A61K 39/00A61K 2039/505C07K 2317/34C07K 14/33Y02A50/30C07K 2319/00C07K 14/245C07K 16/1282C07K 16/02
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Claims

Abstract

The present invention includes portions of soluble recombinant botulinum toxins. The invention also includes soluble fusion proteins which may comprise a portion of a botulinum toxin protein and a non-toxin protein sequence.

Claims

exact text as granted — not AI-modified
1 - 24 . (Canceled)  
     
     
         25 . A soluble portion of a botulinum toxin in a host cell in which the botulinum toxin portion has been recombinantly expressed.  
     
     
         26 . The soluble portion of a botulinum toxin of  claim 25  wherein the botulinum toxin portion is capable of eliciting an immune response.  
     
     
         27 . The soluble portion of a botulinum toxin of  claim 25  wherein the botulinum toxin is type A.  
     
     
         28 . The soluble portion of a botulinum toxin of  claim 25  which includes a non-toxin protein sequence.  
     
     
         29 . The soluble portion of a botulinum toxin of  claim 28  wherein the non-toxin protein sequence is polyhistidine.  
     
     
         30 . The soluble portion of a botulinum toxin of  claim 25  wherein the botulinum toxin is released from the cell.  
     
     
         31 . The soluble portion of a botulinum toxin of  claim 25  wherein the botulinum toxin is isolated.  
     
     
         32 . The soluble portion of a botulinum toxin of  claim 25  wherein the host cell is a prokaryote.  
     
     
         33 . The soluble portion of a botulinum toxin of  claim 32  wherein the prokaryotic host cell is  E. coli.    
     
     
         34 . The soluble portion of a botulinum toxin of claim wherein the host cell is a eukaryote.  
     
     
         35 . The soluble portion of a botulinum toxin of claim wherein the eukaryotic host cell is selected from the group sisting of a mammalian cell, an insect cell and a yeast cell.  
     
     
         36 . The soluble portion of a botulinum toxin of claim wherein the yeast cell is  Pichia pastoris  or  Saccharomyces cerivisiae.

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