Treatment of diabetes and related pathologies

Abstract

Methods for treating diabetes mellitus and related conditions and symptoms are described. The methods are directed to administering a therapeutically effective amount of a compound. Compounds suitable for the invention include pyridoxal-5′-phosphate, pyridoxal, pyridoxamine, pyridoxine, a 3-acylated pyridoxal analogue, a pharmaceutically acceptable acid addition salt thereof, or a mixture thereof. Also disclosed are methods directed to concurrently administering a therapeutically effective amount of a compound with other compounds known in the treatment of diabetes mellitus. In one embodiment, a therapeutically effective amount of a compound is administered concurrently with a therapeutically effective amount of insulin. In another embodiment, a therapeutically effective amount of a compound is administered concurrently with a therapeutically effective amount of a hypoglycemic compound.

1 - 75 . (Canceled)  
     
     
         76 . A method of treating insulin-dependent diabetes mellitus in a mammal comprising: administering to the mammal a therapeutically effective amount of pyridoxal-5′-phosphate, pharmaceutically acceptable acid addition salts thereof, or mixtures thereof.  
     
     
         77 . A method according to  claim 76 , further comprising concurrently administering to the mammal a therapeutically effective amount of insulin.  
     
     
         78 . A method according to  claim 76 , further comprising concurrently administering to the mammal a therapeutically effective amount of a hypoglycemic compound.  
     
     
         79 . A method according to  claim 78 , wherein the hypoglycemic compound is acarbose, acetohexamide, chlorpropamide, glimepiride, glipizide, glyburide, metformin, tolazamide, tolbutamide, or mixtures thereof.  
     
     
         80 . A method according to  claim 78 , wherein the hypoglycemic compound is tolbutamide.  
     
     
         81 . A method according to  claim 78  comprising: 
 concurrently administering to the mammal the pyridoxal-5′-phosphate and the hypoglycemic compound in combination with a therapeutically effective amount of insulin.  
 
     
     
         82 . A method of treating noninsulin-dependent diabetes mellitus in a mammal comprising: concurrently administering to the mammal a therapeutically effective amount of 
 a first compound selected from the group consisting of pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, pyridoxine, a pharmaceutically acceptable acid addition salt thereof, and mixtures thereof; and    a second compound selected from the group consisting of: a hypoglycemic compound, insulin, and a combination thereof.    
     
     
         83 . A method according to  claim 82 , wherein the second compound is a hypoglycemic compound.  
     
     
         84 . A method according to  claim 83 , wherein the hypoglycemic compound is acarbose, acetohexamide, chlorpropamide, glimepiride, glipizide, glyburide, metformin, tolazamide, tolbutamide, or mixtures thereof.  
     
     
         85 . A method according to  claim 83 , wherein the hypoglycemic compound is tolbutamide.  
     
     
         86 . A method according to  claim 82 , wherein the second compound is insulin.  
     
     
         87 . A method according to  claim 82 , wherein the second compound is a combination of insulin and a hypoglycemic compound.