Cell proliferation inhibitors containing anti-glypican 3 antibody

Abstract

Provided is a cell growth inhibitor that can be used for treating diseases based on abnormal cell proliferation, and in particular cancer. The cell growth inhibitor contains an anti-glypican 3 antibody as an active ingredient.

1 . A cell growth inhibitor, containing an anti-grlypican 3 antibody as an active ingredient.  
     
     
         2 . The cell growth inhibitor of  claim 1 , wherein the anti-glypican 3 antibody has cytotoxic activity.  
     
     
         3 . The cell growth inhibitor of  claim 2 , wherein the cytotoxic activity is antibody-dependent cell-mediated cytotoxicity (ADCC) activity or complement-dependent cytotoxicity (CDC) activity.  
     
     
         4 . The cell growth inhibitor of  claim 1 , wherein the cells are carcinoma cells.  
     
     
         5 . The cell growth inhibitor of  claim 4 , wherein the cells are selected from the group consisting of hepatic cancer cells, lung cancer cells, colon cancer cells, mammary cancer cells, prostate cancer cells, leukemia cells, lymphoma cells and pancreatic cancer cells.  
     
     
         6 . The cell growth inhibitor of  claim 5 , wherein the cells are hepatic cancer cells.  
     
     
         7 . The cell growth inhibitor of  claim 1 , wherein the antibody is a monoclonal antibody.  
     
     
         8 . The cell growth inhibitor of  claim 1 , wherein the antibody is a humanized antibody or a chimeric antibody.  
     
     
         9 . An antibody, binding to glypican 3.  
     
     
         10 . The antibody of  claim 9 , having cytotoxic activity.  
     
     
         11 . The antibody of  claim 10 , having cytotoxic activity against hepatic cancer cells.  
     
     
         12 . The antibody of  claim 11 , having cytotoxic activity against an HuH-7 hepatic cancer cell line.