US2004236318A1PendingUtilityA1

Method and system for photoselective vaporization of the prostate, and other tissue

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Assignee: LASERSCOPE INCPriority: Dec 15, 2000Filed: Jun 24, 2004Published: Nov 25, 2004
Est. expiryDec 15, 2020(expired)· nominal 20-yr term from priority
Inventors:Scott A. DavenportSteven C. MurrayTony ColemanHenry GarlichKen ArnoldKester Nahen
A61B 2018/00982A61B 2018/2272A61B 18/22A61B 2018/00547A61B 2018/2015A61B 18/20A61B 2018/00625A61B 2017/00274
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Claims

Abstract

A method for photoselective vaporization of prostate tissue includes delivering laser radiation to the treatment area on the tissue, via an optical fiber for example, wherein the laser radiation has a wavelength and irradiance in the treatment area on the surface of the tissue sufficient because vaporization of a substantially greater volume of tissue than a volume of residual coagulated tissue caused by the laser radiation. The laser radiation is generated using a neodymium doped solid-state laser, including optics comprising LBO or BBO producing a second or higher harmonic output with greater than 20 watts average output power. The delivered laser radiation has a wavelength for example in a range of about 200 nm to about 650 nm, and has an average irradiance in the treatment area greater than about 10 kilowatts/cm 2 , in a spot size of at least 0.05 mm 2 .

Claims

exact text as granted — not AI-modified
What is claimed is:  
     
         1 . A method for photoselective vaporization of tissue, comprising: 
 producing laser radiation using a laser system, including inducing harmonic generation in the laser system using a non-linear crystal comprising at least one of LBO and BBO, and outputting at least one harmonic frequency as said laser radiation; and    delivering said laser radiation to a treatment area on a surface of the tissue, the laser radiation having a wavelength in a range from about 200 to about 1000 nm and having average irradiance in the treatment area sufficient for removal of tissue. 532, endoscope,  claim 10  replace, 20 W, 60 W as in the others. LBO only, BBO only    
     
     
         2 . The method of  claim 1 , wherein the non-linear crystal comprises LBO.  
     
     
         3 . The method of  claim 1 , wherein the non-linear crystal comprises BBO.  
     
     
         4 . The method of  claim 1 , wherein oxyhemoglobin is a primary chromophore of said tissue.  
     
     
         5 . The method of  claim 1 , wherein said tissue comprises prostate tissue.  
     
     
         6 . The method of  claim 1 , including delivering said laser radiation endoscopically  
     
     
         7 . The method of  claim 1 , wherein the wavelength is about 532 nm.  
     
     
         8 . The method of  claim 1 , the laser radiation being absorbed substantially completely by the tissue within about 1 mm of the surface, and having average irradiance in the treatment area greater than 10 kiloWatts/cm 2  in a spot size at least about 0.05 mm 2 .  
     
     
         9 . The method of  claim 1 , the laser radiation being absorbed substantially completely by the tissue within about 1 mm of the surface, and having average irradiance in the treatment area greater than 10 kiloWatts/cm 2  in a spot size between about 0.1 and 0.8 mm 2  in the treatment area.  
     
     
         10 . The method of  claim 1 , the laser radiation being absorbed substantially completely by the tissue within about 1 mm of the surface, and having average irradiance in the treatment area greater than 30 kiloWatts/cm 2  in the treatment area.  
     
     
         11 . The method of  claim 1 , wherein the delivered laser radiation has an average irradiance in the treatment area greater than 20 kiloWatts/cm 2 .  
     
     
         12 . The method of  claim 1 , including delivering a flow of irrigant to the treatment area, and wherein the delivered laser radiation passes through some of the irrigant before reaching the surface of the tissue.  
     
     
         13 . The method of  claim 1 , wherein said delivering comprises using a transurethreal cystoscope, with an optical fiber having a side firing optical element directing laser radiation from the fiber to a treatment area on the tissue, and placing said side firing optical element within about 1 mm, or less, of the treatment area.  
     
     
         14 . The method of  claim 1 , wherein said delivering comprises using a endoscope, with an optical fiber directing laser radiation from the fiber to a treatment area on the tissue.  
     
     
         15 . The method of  claim 1 , including applying only local anesthetic during said delivering.  
     
     
         16 . The method of  claim 1 , wherein said producing includes generating said laser radiation using a solid state laser with greater than 60 Watts average output power.  
     
     
         17 . The method of  claim 1 , wherein said producing includes generating said laser radiation using a solid state laser with greater than 20 Watts average output power.  
     
     
         18 . An apparatus for photoselective vaporization of tissue, comprising: 
 a laser including non-linear optics producing a second or higher harmonic output laser radiation having a wavelength in a range from about 200 nm to about 1000 nm, wherein the non-linear optics comprise at least one of LBO and BBO;    an optical fiber coupled to the laser, adapted to direct laser radiation from the fiber to a treatment area on the tissue; and    laser and optical fiber being adapted to deliver the laser radiation with an average irradiance in the treatment area sufficient for tissue removal.    
     
     
         19 . The apparatus of  claim 18 , wherein the non-linear crystal comprises LBO.  
     
     
         20 . The apparatus of  claim 18 , wherein the non-linear crystal comprises BBO.  
     
     
         21 . The apparatus of  claim 18 , wherein oxyhemoglobin is a primary chromophore of said tissue.  
     
     
         22 . The apparatus of  claim 18 , wherein said tissue comprises prostate tissue.  
     
     
         23 . The apparatus of  claim 18 , wherein the laser comprises a solid state laser with greater than 60 Watts average output power.  
     
     
         24 . The apparatus of  claim 18 , wherein the laser comprises a solid state laser with greater than 20 Watts average output power.  
     
     
         25 . The apparatus of  claim 18 , wherein the wavelength is about 532 nm.  
     
     
         26 . The apparatus of  claim 18 , wherein the average irradiance is greater than 10 kiloWatts/cm 2  and the optical fiber is adapted to cause a spot size of at least about 0.05 mm 2  in the treatment area.  
     
     
         27 . The apparatus of  claim 18 , wherein the laser comprises a Neodymium doped solid state laser medium.  
     
     
         28 . The apparatus of  claim 18 , wherein the laser and optical fiber are adapted to deliver laser radiation having an average irradiance in the treatment area greater than 20 kiloWatts/cm 2 .  
     
     
         29 . The apparatus of  claim 18 , wherein the laser and optical fiber are adapted to deliver laser radiation having an average irradiance in the treatment area greater than 30 kiloWatts/cm 2 .  
     
     
         30 . The apparatus of  claim 18 , wherein the laser and optical fiber are adapted to deliver laser radiation having a spot size is less than about 0.8 mm 2  in the treatment area.  
     
     
         31 . The apparatus of  claim 18 , wherein the optical fiber includes a side firing tip, and is further adapted for placement of said side firing tip within about 1 mm, or less, of the treatment area.  
     
     
         32 . The apparatus of  claim 18 , wherein the laser includes a Q-switch.  
     
     
         33 . The apparatus of  claim 18 , including an endoscope.

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