Krill and/or marine extracts for prevention and/or treatment of cardiovascular diseases arthritis, skin cancer diabetes, premenstrual syndrome and transdermal transport

Abstract

The present invention relates to a method of treatment and/or prevention of cardiovascular disease, rheumatoid arthritis, skin cancer, premenstrual syndrome, diabetes and transdermal transport enhancement. The method comprises the administration of a therapeutically effective amount of krill and/or marine oil to a patient. The present invention also relates to a composition for the treatment and/or prevention of these diseases.

1 - 83 . (Cancelled)  
     
     
         84 . A composition comprising an amount of krill oil effective for decreasing cholesterol, inhibiting platelet adhesion, inhibiting artery plaque formation, preventing hypertension, controlling arthritis symptoms, preventing skin cancer, enhancing transdermal transportation of dermatological topical therapeutic applications, enhancing transdermal transportation of dermatological cosmetic applications, reducing symptoms of premenstrual syndrome, or controlling blood glucose level in a patient, and a pharmaceutically acceptable carrier, wherein said krill oil is obtained from a process comprising the steps of: 
 a) placing marine or aquatic krill in a ketone solvent, to obtain a first extraction of a soluble lipid fraction from said marine or aquatic krill;    b) separating the extraction into a first liquid and a first solid contents;    c) evaporating the ketone solvent present in the first liquid contents to recover a first lipid rich fraction;    d) placing said first solid contents in an organic solvent selected from the group of consisting of alcohol and esters of acetic acid, to achieve a second extraction of soluble lipid fraction;    e) separating the second extraction into a second liquid and a second solid contents;    f) evaporating the organic solvent from the second liquid contents to recover a second lipid rich fraction; and    g) recovering the solid contents.    
     
     
         85 . A composition according to  claim 84 , wherein the ketone solvent is acetone.  
     
     
         86 . A composition according to  claim 84 , wherein the organic solvent is ethanol, isopropanol, t-butanol, or ethyl acetate  
     
     
         87 . A composition according to  claim 84 , wherein the composition comprises Eicosapentanoic acid, Docosahexanoic acid, Phosphatidylcholine, Phosphatidylinositol, Phosphatidylserine, Phosphatidylethanolamine, Sphingomyelin, a-tocopherol, Astaxanthin, and flavonoid.  
     
     
         88 . A composition of  claim 87 , further comprising at least one of the group consisting of Linoleic acid, Alpha-linoleic acid, arachidonic acid, oleic acid, palmitic acid, palmitoleic acid, stearic acid, cholesterol, triglycerides, monoglycerides, all-trans retinol, canthaxanthin, β-carotene, zinc, selenium, nervonic acid, sodium, potassium and calcium.  
     
     
         89 . A composition of  claim 84 , wherein the composition comprising an effective amount for decreasing cholesterol in a patient.  
     
     
         90 . A composition of  claim 84 , wherein the composition comprising an effective amount for inhibiting platelet adhesion or artery plaque formation in a patient.  
     
     
         91 . A composition of  claim 84 , wherein the composition comprising an effective amount for preventing hypertension in a patient.  
     
     
         92 . A composition of  claim 84 , wherein the composition comprising an effective amount for controlling arthritis symptoms in a patient.  
     
     
         93 . A composition of  claim 92 , wherein the arthritis is rheumatoid arthritis or osteoarthritis.  
     
     
         94 . A composition of  claim 84 , wherein the composition comprising an effective amount for preventing skin cancer in a patient.  
     
     
         95 . A composition of  claim 84 , wherein the composition comprising an effective amount for enhancing transdermal transportation of dermatological topical therapeutic applications, or enhancing transdermal transportation of dermatological cosmetic applications decreasing cholesterol in a patient.  
     
     
         96 . A composition of  claim 84 , wherein the composition comprising an effective amount for reducing symptoms of premenstrual syndrome in a patient.  
     
     
         97 . The composition of  claim 84 , wherein the composition comprising an effective amount for controlling blood glucose level in a patient.  
     
     
         98 . A method for decreasing cholesterol, inhibiting platelet adhesion, inhibiting artery plaque formation, preventing hypertension, controlling arthritis symptoms, preventing skin cancer, enhancing transdermal transportation of dermatological topical therapeutic applications, enhancing transdermal transportation of dermatological cosmetic applications, reducing symptoms of premenstrual syndrome, or controlling blood glucose level in a patient in need thereof, said method comprising administering an effective amount of the composition of  claim 84  to said patient.  
     
     
         99 . A method of  claim 98 , wherein said administering is effected orally.  
     
     
         100 . A method of  claim 99 , wherein a quantity in a range of about 1 to almost 4.8 grams per day of krill oil is administered.  
     
     
         101 . A method of  claim 100 , wherein said quantity is about 4.8 grams.  
     
     
         102 . A method of  claim 98 , which is for decreasing cholesterol in a patient.  
     
     
         103 . A method of  claim 98 , which is for inhibiting platelet adhesion and artery plaque formation in a patient.  
     
     
         104 . A method of  claim 98 , which is for preventing hypertension in a patient.  
     
     
         105 . A method of  claim 98 , which is for controlling arthritis symptoms in a patient.  
     
     
         106 . A method of  claim 105 , wherein the arthritis is rheumatoid arthritis or osteoarthritis.  
     
     
         107 . A method of  claim 98 , which is for preventing skin cancer in a patient.  
     
     
         108 . A method of  claim 98 , which is for enhancing transdermal transportation of dermatological topical therapeutic applications, or enhancing transdermal transportation of dermatological cosmetic applications decreasing cholesterol in a patient.  
     
     
         109 . A method of  claim 98 , which is for reducing symptoms of premenstrual syndrome in a patient.  
     
     
         110 . A method of  claim 98 , which is for controlling blood glucose level in a patient.