Composition containing dipeptide of histidine and alanine for reducing uric acid and method for reducing uric acid using the dipeptide

Abstract

The present invention relates to a composition comprising an effective amount or an effective amount of one or more dipeptides consisting of histidine or the functional equivalent thereof and alanine or the functional equivalent thereof for reducing uric acid in a subject. The invention also provides a method for the treatment of gout or the amelioration of symptoms related to a high level of uric acid comprising the step of administering or applying the above-mentioned dipeptides to a subject.

1 . A composition for reducing uric acid in a subject comprising an effective amount of one or more dipeptides consisting of histidine or the functional equivalent thereof and alanine or the functional equivalent thereof.  
     
     
         2 . The composition of  claim 1 , wherein the functional equivalent of histidine is methylhistidine or histamine.  
     
     
         3 . The composition of  claim 1 , wherein the functional equivalent of alanine is γ-aminobutyric acid.  
     
     
         4 . The composition of  claim 1 , wherein the one or more dipeptides are selected from carnosine, anserine, carcinine, homocarnosine and ophidine.  
     
     
         5 . The composition of  claim 4 , wherein the dipeptides are carnosine and anserine.  
     
     
         6 . The composition of  claim 5 , wherein carnosine and anserine comprise about 5-30% w/w and about 95-70% w/w of the total amount of the dipeptides, respectively.  
     
     
         7 . The composition of  claim 6 , wherein carnosine and anserine comprise about 7% w/w and about 90% w/w of the total amount of the dipeptides, respectively.  
     
     
         8 . The composition of  claim 1 , which is administered or applied to the subject by an oral or parenteral route.  
     
     
         9 . The composition of  claim 1 , which is administered or applied to provide an amount of about 8 mg to about 50 mg of the one or more dipeptides per day.  
     
     
         10 . The composition of  claim 9 , which is administered or applied to provide an amount of about 10 mg to about 45 mg of the one or more dipeptides per day.  
     
     
         11 . The composition of  claim 1 , further comprising oligopeptides, free amino acids, carnitine, and a pharmaceutically or physiologically acceptable excipient.  
     
     
         12 . The composition of  claim 1 , which is administered or applied to the subject in combination with uricosuric agents, simultaneously or sequentially.  
     
     
         13 . The composition of  claim 12 , wherein the uricosuric agents are selected from Benzbromarone, Probenecid, Allopurinol, Bucolome, Cinchophan and Colchicine.  
     
     
         14 . The composition of  claim 1 , which is used as a medicament for the treatment of gout or the amelioration of symptoms related to a high level of uric acid selected from muscle spasm, localized swelling, inflammation, joint pains, muscle fatigue, stress feelings and myocardial infraction.  
     
     
         15 . The composition of  claim 1 , which is used as a dietary supplement.  
     
     
         16 . A method for reducing uric acid in a subject in need thereof, comprising the step of administering or applying to the subject an effective amount of one or more dipeptides consisting of histidine or the functional equivalent thereof and alanine or the functional equivalent thereof.  
     
     
         17 . The method of  claim 16 , wherein the functional equivalent of histidine is methylhistidine or histamine.  
     
     
         18 . The method of  claim 16 , wherein the functional equivalent of alanine is γ-aminobutyric acid.  
     
     
         19 . The method of  claim 16 , wherein the one or more dipeptides are selected from carnosine, anserine, carcinine, homocarnosine and ophidine.  
     
     
         20 . The method of  claim 19 , wherein the dipeptides are carnosine and anserine.  
     
     
         21 . The method of  claim 20 , wherein carnosine and anserine comprise about 5-30% w/w and about 95-70% w/w of the total amount of the dipeptides, respectively.  
     
     
         22 . The method of  claim 21 , wherein carnosine and anserine comprise about 7% w/w and about 90% w/w of the total amount of the dipeptides, respectively.  
     
     
         23 . The method of  claim 16 , wherein the one or more dipeptides is administered or applied to the subject by an oral or parenteral route.  
     
     
         24 . The method of  claim 16 , wherein the effective amount of the one or more dipeptides is about 8 mg to about 50 mg per day.  
     
     
         25 . The method of  claim 24 , wherein the effective amount of the one or more dipeptides is about 10 mg to about 45 mg per day.  
     
     
         26 . The method of  claim 16 , comprising the step of administering or applying to the subject an effective amount of a composition for reducing uric acid in a subject comprising an effective amount of one or more dipeptides consisting of histidine or the functional equivalent thereof and alanine or the functional equivalent thereof.  
     
     
         27 . The method of  claim 16 , which is used for the treatment of gout or the amelioration of symptoms related to a high level of uric acid selected from muscle spasm, localized swelling, inflammation, joint pains, muscle fatigue, stress feelings and myocardial infraction.  
     
     
         28 . The method of  claim 16 , wherein the one or more dipeptides are administered or applied in combination with uricosuric agents, simultaneously or sequentially.  
     
     
         29 . The method of  claim 28 , wherein the uricosuric agents are selected from Benzbromarone, Probenecid, Allopurinol, Bucolome, Cinchophan and Colchicine.