Pyrimidine derivatives useful as inhibitors of PKC-theta

Abstract

Disclosed are novel compounds of formula (I): wherein R 1 , R 2 and R 3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

We claim:  
     
         1 . A compound of the following formula (I):  
       
         
           
           
               
               
           
         
         wherein:  
         R 1  is C 1-8 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-8 alkyl, naphthyl, quinolinyl, aryl-C 1-8 alkyl, or heteroaryl-C 1-8 alkyl, wherein in each of the C 1-8 alkyl groups a methylene group may optionally be replaced by —NHC(O)— or —C(O)NH—, and wherein each of the C 1-8 alkyl groups is optionally substituted by an oxo group or one or more C 1-3 alkyl groups wherein two alkyl substituents on the same carbon atom of a C 1-8 alkyl group may optionally be combined to form a C 2-5  alkylene bridge, and wherein the aryl group is optionally substituted on adjacent carbon atoms by a C 3-6 alkylene bridge group wherein a methylene group is optionally replaced by an oxygen, —S—, —S(O)—, —SO 2 — or —N(R 6 )-;  
         or R 1  has the following structure:  
         
           
             
             
                 
                 
             
           
         
         wherein x and y are independently 0, 1, 2, 3 or 4, provided that x+y is 2 to 4, z is 0, 1 or 2, and one or two CH 2  groups in the ring may optionally be replaced by —O—, —S—, —S(O)—, —SO 2 — or —N(R 6 );  
         wherein each R 1  group is optionally substituted by one or more of the following groups: C 1-6 alkyl, C 3-6 cycloalkyl, halogen, nitro, hydroxy, C 1-6 alkyloxy, C 1-6 alkylthio, aryl, arylC 1-6 alkyl, aryloxy, arylthio, aminosulfonyl, or amino optionally substituted by one or two C 1-6 alkyl groups, wherein each aryl group is optionally substituted by one or more C 1-6 alkyl, halogen, nitro, hydroxy or amino optionally substituted by one or two C 1-6 alkyl groups, and wherein in each of the C 1-6 alkyl groups a methylene group may optionally be replaced by —NHC(O)— or —C(O)NH—, and wherein each of the C 1-6 alkyl groups is optionally substituted by one or more halogens;  
         R 2  is selected from the following groups:  
         
           
             
             
                 
                 
             
           
         
         wherein:  
         n is an integer from 3 to 8;  
         p is an integer from 1 to 3;  
         q is an integer from 0 to 3;  
         R 4  and R 5  are each independently selected from hydrogen, C 1-6 alkyl, arylC 1-6 alkyl, or amidino, wherein each aryl group is optionally substituted by one or more C 1-6 alkyl, halogen, nitro, hydroxy or amino optionally substituted by one or two C 1-6 alkyl groups, and wherein each of the C 1-6 alkyl groups is optionally substituted by one or more halogens, and wherein the amidino is optionally substituted by one to three C 1-6 alkyl;  
         R 6  is hydrogen or C  1 6alkyl;  
         wherein each R 2  group is optionally substituted by one or more C 1-6 alkyl, C 1-6 alkoxy, CN, —OH, —NH 2  or halogen;  
         R 3  is halogen, cyano, nitro, C 1-6 alkyl, C 1-6 alkyloxycarbonyl or aminocarbonyl, wherein each of the C 1-6 alkyl groups is optionally substituted by one or more halogens;  
         or a tautomer, pharmaceutically acceptable salt, solvate, or amino-protected derivative thereof, with the proviso that the specific compounds of U.S. patent application Publication No. 2003/0171359 A1 are excluded.  
       
     
     
         2 . A compound of formula (I) according to  claim 1 , wherein: 
 R 1  is aryl-C 1-4 alkyl or heteroaryl-C 1-4 alkyl, wherein in each of the C 1-4 alkyl groups a methylene group may optionally be replaced by —NHC(O)— or —C(O)NH—, and wherein each of the C 1-4 alkyl groups is optionally substituted by an oxo group or one or more C 1-3 alkyl groups wherein two alkyl substituents on the same carbon atom of a C 1-4 alkyl group may optionally be combined to form a C 2-5  alkylene bridge, and wherein the aryl group is optionally substituted on adjacent carbon atoms by a C 3-6 alkylene bridge group wherein a methylene group is optionally replaced by an oxygen, sulfur or —N(R 6 )-;    or R 1  has the following structure:                          wherein x and y are independently 0, 1, 2 or 3, provided that x+y is 2 to 3, and z is 0 or 1;    wherein “heteroaryl” is defined as pyridyl, furyl, thienyl, pyrrolyl, imidazolyl, or indolyl;    wherein each R 1  group is optionally substituted by one or more of the following groups: C 1-6 alkyl, Cl, Br, F, nitro, hydroxy, CF 3 , —OCF 3 , —OCF 2 H, —SCF 3 , C 1-4 alkyloxy, C 1-4 alkylthio, phenyl, benzyl, phenyloxy, phenylthio, aminosulfonyl, or amino optionally substituted by one or two C 1-3 alkyl groups;    R 2  is selected from the following groups:                          wherein:    n is an integer from 5 to 7;    p is an integer from 1 to 2;    q is an integer from 1 to 2;    R 4  and R 5  are each independently selected from hydrogen, C 1-6 alkyl, arylC 1-6 alkyl, or amidino;    R 6  is hydrogen;    R 3  is Br, Cl, F, cyano or nitro;    or a tautomer, pharmaceutically acceptable salt, solvate, or amino-protected derivative thereof;    
     
     
         3 . A compound of formula (I) according to  claim 1 , wherein: 
 R 1  is phenyl-C 1-4 alkyl or naphthylC 1-2 alkyl,    wherein each R 1  group is optionally substituted by one or more of the following groups: methyl, Cl, Br, F, nitro, hydroxy, CF 3 , —OCF 3 , —SCF 3 , C 1-4 alkyloxy or C 1-4 alkylthio;    R 2  is selected from the following groups:                          wherein:    R 4  and R 5  are each independently selected from hydrogen, C 1-3  alkyl, or amidino;    R 3  is Br, Cl, cyano or nitro;    or a tautomer, pharmaceutically acceptable salt, solvate, or amino-protected derivative thereof;    
     
     
         4 . A compound of formula (I) according to  claim 1 , wherein: 
 R 1  is phenylCH 2 —   wherein the phenyl group is optionally substituted by one or more of the following groups: methyl, Cl, Br, F, nitro, hydroxy, CF 3 , —OCF 3 , —SCF 3 , C 1-4 alkyloxy or C 1-4 alkylthio;    R 2  is selected from the following groups:                          R 3  is nitro;    R 4  and R 5  are each independently selected from hydrogen, methyl, or amidino;    or a tautomer, pharmaceutically acceptable salt, solvate, or amino-protected derivative thereof.    
     
     
         5 . A compound according to  claim 1  selected from: 
 ethyl 4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-2-[(2-chlorobenzyl)amino]pyrimidine-5-carboxylate;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[(2S)-1,2,3,4-tetrahydronaphthalen-2-yl]pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[(1R)-1,2,3,4-tetrahydronaphthalen-2-yl]pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[(1S)-1,2,3,4-tetrahydronaphthalen-2-yl]pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(4-chlorophenyl)ethyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(2-methylphenyl)ethyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(3-methylphenyl)ethyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(4-methylphenyl)ethyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(2-fluorophenyl)ethyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(3-fluorophenyl)ethyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(4-fluorophenyl)ethyl]-5-nitropyrimidine-2,4-diamine;  
 N 2 -(2-aminobenzyl)-N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3,5-dimethoxybenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[3,5-bis(trifluoromethyl)benzyl]-5-nitropyrimidine-2,4-diamine;  
 {3-[({2-[(2-chlorobenzyl)amino]-5-nitropyrimidin-4-yl}amino)methyl]phenyl}methane amine;  
 2-({[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}methyl)phenol;  
 N 2 -(5-amino-2-chlorobenzyl)-N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitropyrimidine-2,4-diamine;  
 4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-2-[(2-chlorobenzyl)amino]pyrimidine-5-carboxamide;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chlorobenzyl)-5-fluoropyrimidine-2,4-diamine;  
 3-({[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}methyl)-N-[2-(2-methlphenyl)ethyl]benzamide;  
 (1S,2R)-2-({[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}methyl)cyclohexanol;  
 (1R,2R)-2-({[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}methyl)cyclohexanol;  
 methyl 4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-2-[(2-chlorobenzyl)amino]pyrimidine-5-carboxylate;  
 4-{[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}-N-[2-(2-methlphenyl)ethyl]butanamide;  
 5-{[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}-N-[2-(2-methlphenyl)ethyl]pentanamide;  
 6-{[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}-N-[2-(2-methylphenly)ethyl]hexanamide;  
 (1R,3R)-3-({[4-({[4-(aminomethyl) cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}methyl)-4,4-dimethylcyclohexanol;  
 N 4 -({4-cis-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -( 1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;  
 N 2 -[2-(methylthio)benzyl]-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;  
 5-nitro-N 4 -(piperidin-4-ylmethyl)-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;  
 N 2 -(1-naphthylmethyl)-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;  
 N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine -2,4-diamine;  
 N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;  
 N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{4-[(dimethylamino)methyl]benzyl}-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{4-[(dimethylamino)methyl]benzyl}-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;  
 N 4 -{4-[(dimethylamino)methyl]benzyl}-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -[(1-methylpiperidin-4-yl)methyl]-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -[(1-methylpiperidin-4-yl)methyl]-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine  
 N 4 -[(1-methylpiperidin-4-yl)methyl]-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;  
 N 2 -(2-chlorobenzyl)-N 4 -[(1-methylpiperidin-4-yl)methyl]-5-nitropyrimidine-2,4-diamine;  
 N 2 -(2-methoxybenzyl)-N 4 -[(1-methylpiperidin-4-yl)methyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-methoxybenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[2-(trifluoromethyl)benzyl]pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methly}-N 2 -(2,4-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-methoxybenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[4-fluoro-2-(trifluoromethyl)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(pyridin-2-ylmethyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-bromobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,4-dimethoxybenzyl)-5-nitropyrimidine-2,4diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-chloro-5-(trifluoromethyl)benzyl]-5-nitropyrimide-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,5-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[2-(trifluoromethoxy)benzyl]pyrimidine-2,4-diamine;  
 4-{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-6-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-furylmethyl)-5-nitropyrimidine-2,4-diamine  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(thien-2-ylmethyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chlorobenzyl)-5-methylpyrimidine-2,4-diamine;  
 N 4 -(6-aminohexyl)-N 2 -(2-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -[4-(aminomethyl)benzyl]-N 2 -(2-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -(7-aminoheptyl)-N 2 -(2-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[3-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(1-methyl-1-phenylethyl)-5-nitropyrimidine-2,4-diamine;  
 4-(4,4′-bipiperidin-1-yl)-N-(2-chlorobenzyl)-5-nitropyrimidin-2-amine;  
 N 2 -(2-chlorobenzyl)-N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-5-nitropyrimidine-2,4-diamine;  
 4-{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,5-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[4-(difluoromethoxy)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-ethoxybenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[(1S)-1-phenylethyl]pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-chloro-2-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(4-pentylbenzyl)pyrimidine-2,4-diamine  
 4-{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-butoxybenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dimethoxybenzyl)-5-nitropyrimidine-2,4-diamine  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,5-dimethoxybenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 2 -(2-chlorobenzyl)-N 4 -[7-(dimethylamino)heptyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(1,1 ′-biphenyl-2-ylmethyl)-5-nitropyrimidine -2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,4-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-fluoro-4-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -(2-chlorobenzyl)pyrimidine-2,4-diamine  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,6-dimethoxybenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,6-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-fluoro-3-(trifluoromethyl)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-chloro-2-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(1-phenylcyclopropyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[1-(2-chlorophenyl)-1-methylethyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dihydro-1-benzofuran-5-ylmethyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[(1,5-dimethyl-1H-pyrrol-2-yl)methyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-bromobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dimethylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,4-dimethylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,5-dimethylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-fluoro-5-(trifluoromethyl)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}primidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(6-chloro-2-fluoro-3-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-6-fluoro-3-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -2-naphthyl-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-fluoro-4-(trifluoromethyl)benzyl]-5-nitropryimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-chloro-2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(5-chloro-2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 4-{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-chloro-2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[5-fluoro-2-(trifluoromethyl)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(5-chloro-2-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-difluoro-4-methylbenzyl)-5-nitropyrimide-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(5-fluoro-2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -1-naphthyl-5-nitropyrimidine-2,4-diamine;  
 {4-trans-[({2-[(2-chlorobenzyl)amino]-5-nitropyrimidin-4-yl}amino)methyl]cyclohexyl}methanol;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -(2,5-dichlorobenzyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -(2,4-dichlorobenzyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -(2-bromobenzyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(cyclohexylmethyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-nm-[2-(trifluoromethoxy)benzyl]pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -[2-(trifluoromethyl)benzyl]pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(difluoromethoxy)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[3-(difluoromethoxy)benzyl]-5-nitropyrimidine-2,4-diamine;  
 4-{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-4-fluoro benzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-3,6-difluorobenzyl)-5-nitropyrimidine -2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(2,3,5-trifluorobenzyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(2,3,4,5-tetrafluorobenzyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[(1R)-1-phenylethyl]pyrimidine-2,4-diamine;  
 4-{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -2,3-dihydro- 1 H-inden-2-yl-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[(1S)-2,3-dihydro-1H-inden-1-yl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[(1R)-2,3-dihydro-1H-inden-1-yl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-chloro-1-naphthyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-methoxy-2-naphthyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -quinolin-6-ylpyrimidine-2,4-diamine;  
 N 4 -{[4-trans-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,5-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-trans-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(2-chlorophenyl)ethyl]-5-nitropyrimidine -2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(3-chlorophenyl)ethyl]-5-nitropyrimidine -2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-6-phenoxybenzyl)-5-nitropyrimidine-2,4-diamine;  
 4-{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -2-naphthylpyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -(1-naphthylmethyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(pyridin-3-ylmethyl)pyrimidine-2,4-diamine;  
 4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-2-[(2-chlorobenzyl)amino]pyrimidine-5-carbonitrile;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[4-(dimethylamino)benzyl]-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-trans-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-bromobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -(7-aminoheptyl)-N 2 -(2-bromobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -(7-aminoheptyl)-N 2 -(2,5-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N-({4-[({2-[(2-chlorobenzyl)amino]-5-nitropyrimidin-4-yl}amino)methyl]cyclohexyl}methyl)guanidine;  
 N 2 -(3-aminobenzyl)-N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(2-nitrobenzyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(2-bromophenyl)ethyl]-5-nitropyrimidine -2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-bromobenzyl)-5-chloropyrimidine-2,4-diamine;  
 (4-{[(2-{[2-(1H-indol-3-yl)ethyl]amino}-5-nitropyrimidin-4-yl)amino]methyl}cyclohexyl)methanaminium chloride;  
 N-({3-[({2-[(2-chlorobenzyl)amino]-5-nitropyrimidin-4-yl}amino)methyl]cyclohexyl}methyl)guanidine;  
 3-({[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}methyl)phenol;  
 (4-{[(2-{[2-(1H-imidazol-4-yl)ethyl]amino}-5-nitropyrimidin-4-yl)amino]methyl}cyclohexyl)methanaminium chloride;  
 N 2 -(2-chlorobenzyl)-N 4 -({4-cis-[(dimethylamino)methyl]cyclohexyl}methyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-chloro-N 2 -(2-chlorobenzyl)pyrimidine-2,4-diamine;  
 N 2 -(2-chlorobenzyl)-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(2-phenylethyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(3-phenylpropyl)pyrimidine-2,4-diamine  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(4-phenylbutyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(2-phenylpropyl)pyrimidine-2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(4-methoxyphenyl)ethyl]-5-nitropyrimidine -2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(3-methoxyphenyl)ethyl]-5-nitropyrimidine -2,4-diamine;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(2-methoxyphenyl)ethyl]-5-nitropyrimidine -diamine;  
 4-[({2-[(2-chlorobenzyl)amino]-5-nitropyrimidin-4-yl}amino)methyl]piperidine-1-carboximide;  
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3,5-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 N 4 -(5-aminopentyl)-N 2 -(2-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;  
 2-(benzylamino)-4-(1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-5-trifluoromethyl-pyrimidine;  
 2-(4-chlorobenzylamino)-4-(1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-5-nitro-pyrimidine;  
 2-(2-chlorobenzylamino)-4-(1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-5-nitro-pyrimidine;  
 2-(benzylamino)-4-(1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-5-nitro-pyrimidine;  
 or a tautomer, pharmaceutically acceptable salt, solvate, or amino-protected derivative thereof.  
 
     
     
         6 . A compound according to  claim 1 , selected from: 
 N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[(2R)-1,2,3,4-tetrahydronaphthalen-2-yl]pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(4-chlorophenyl)ethyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(3-methylphenyl)ethyl]-5-nitropyrimidine-2,4-diamine;    N 4 -[4-{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(4-methylphenyl)ethyl]-5-nitropyrimide-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(3-fluorophenyl)ethyl]-5-nitropyrimidine -2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(4-fluorophenyl)ethyl]-5-nitropyrimidine -2,4-diamine;    (1R,3R)-3-({[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}methyl)-4,4-dimethylcyclohexanol;    N 4 -({4-cis-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;    N 2 -[2-(methylthio)benzyl]-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;    5-nitro-N 4 -(piperidin-4-ylmethyl)-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 2 -(1-naphthylmethyl)-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;    N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{4-[(dimethylamino)methyl]benzyl}-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{4-[(dimethylamino)methyl]benzyl}-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 4 -[(1-methylpiperidin-4-yl)methyl]-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -[(1-methylpiperidin-4-yl)methyl]-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-methoxybenzyl)-5-nitropyrimidine-2,4-diamine    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[2-(trifluoromethyl)benzyl]pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,4-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[4-fluoro-2-(trifluoromethyl)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-bromobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-chloro-5-(trifluoromethyl)benzyl]-5-nitroprimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,5-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[2-(trifluoromethoxy)benzyl]pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-6-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[3-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chlorobenzyl)-5-nitropyrimidine-2,4-diamine    N 2 -(2-chlorobenzyl)-N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,5-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-ethoxybenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-chloro-2-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(1,1′-biphenyl-2-ylmethyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,4-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,6-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-fluoro-3-(trifluoromethyl)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-chloro-2-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-bromobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dimethylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(6-chloro-2-fluoro-3-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-6-fluoro-3-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -2-naphthyl-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-chloro-2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(5-chloro-2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(3-chloro-2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[5-fluoro-2-(trifluoromethyl)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(5-chloro-2-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-difluoro-4-methylbenzyl)-5-nitropyrimidine-2,4diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(5-fluoro-2-methylbenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -(2,5-dichlorobenzyl)pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -(2-bromobenzyl)pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(cyclohexylmethyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -[2-(trifluoromethyl)benzyl]pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(difluoromethoxy)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-4-fluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chloro-3,6-difluorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(2,3,5-trifluorobenzyl)pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -2,3-dihydro-1H-inden-2-yl-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-chloro-1-naphthyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(4-methoxy-2-naphthyl)-5-nitropyrimidine-2,4-diamine;    4-{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -quinolin-6-ylpyrimidine-2,4-diamine;    N 4 -{[4-trans-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(2-chlorophenyl)ethyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(3-chlorophenyl)ethyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-bromo-N 2 -2-naphthylpyrimidine-2,4-diamine;    4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-2-[(2-chlorobenzyl)amino]pyrimidine-5-carbonitrile;    N 4 -{[4-trans-(aminomethyl)cyclohexyl]methyl]-}N 2 -(2-bromobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -(7-aminoheptyl)-N 2 -(2-bromobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -(7-aminoheptyl)-N 2 -(2,5-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N-({4-[({2-[(2-chlorobenzyl)amino]-5-nitropyrimidin-4-yl}amino) methyl]cyclohexyl}methyl)guanidine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(2-nitrobenzyl)pyrimidine-2,4-diamine    4-{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(2-bromophenyl)ethyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-bromobenzyl)-5-chloropyrimidine-2,4-diamine;    N-({3-[({2-[(2-chlorobenzyl)amino]-5-nitropyrimidin-4-yl}amino)methyl]cyclohexyl}methyl)guanidine;    3-({[4-({[4-(aminomethyl)cyclohexyl]methyl}amino)-5-nitropyrimidin-2-yl]amino}methyl)phenol;    N 2 -(2-chlorobenzyl)-N 4 -({4-cis-[(dimethylamino)methyl]cyclohexyl}methyl)-5-nitropyrimidine-2,4-diamine;    N 2 -(2-chlorobenzyl)-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(2-phenylethyl)pyrimidine-2,4-diamine    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -(4-phenylbutyl)pyrimidine-2,4-diamine    or a tautomer, pharmaceutically acceptable salt, solvate, or amino-protected derivative thereof.    
     
     
         7 . A compound according to  claim 1 , selected from: 
 N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;    N 2 -[2-(methylthio)benzyl]-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;    5-nitro-N 4 -(piperidin-4-ylmethyl)-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 2 -(1-naphthylmethyl)-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;    N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{4-[(dimethylamino)methyl]benzyl}-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{4-[(dimethylamino)methyl]benzyl}-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 4 -[(1-methylpiperidin-4-yl)methyl]-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -[(1-methylpiperidin-4-yl)methyl]-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-methoxybenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -[2-(trifluoromethoxy)benzyl]pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[3-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-chlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 2 -(2-chlorobenzyl)-N 4 -({4-[(dimethylamino)methyl]cyclohexyl}methyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-bromobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -[2-(methylthio)benzyl]-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-5-nitro-N 2 -{2-[(trifluoromethyl)thio]benzyl}pyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(1-naphthylmethyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2,3-dichlorobenzyl)-5-nitropyrimidine-2,4-diamine;    N 4 -{[4-(aminomethyl)cyclohexyl]methyl}-N 2 -(2-bromobenzyl)-5-nitropyrimidine-2,4-diamine;    N 2 -(2-chlorobenzyl)-5-nitro-N 4 -(piperidin-4-ylmethyl)pyrimidine-2,4-diamine;    or a tautomer, pharmaceutically acceptable salt, solvate, or amino-protected derivative thereof.    
     
     
         8 . A pharmaceutical composition comprising a compound according to  claim 1 , and at least one pharmaceutically acceptable carrier or adjuvant.  
     
     
         9 . A method of treating a disease or disorder that is mediated or sustained through the activity of PKC-theta in a patient comprising administering to said patient a therapeutically effective amount of a compound according to  claim 1 .  
     
     
         10 . A method of treating a disease or disorder associated with the activation of T cells in a patient comprising administering to said patient a therapeutically effective amount of a compound according to  claim 1 .  
     
     
         11 . A method of treating an immunological disorder in a patient comprising administering to said patient a therapeutically effective amount of a compound according to  claim 1 .  
     
     
         12 . A method of treating an inflammatory disease, an autoimmune disease, organ and bone marrow transplant rejection, acute or chronic inflammation, allergies, contact dermatitis, psoriasis, rheumatoid arthritis, multiple sclerosis, type I diabetes, inflammatory bowel disease, Guillain-Barre syndrome, Crohn's disease, ulcerative colitis, graft versus host disease or lupus erythematosus in a patient comprising administering to said patient a therapeutically effective amount of a compound according to  claim 1 .  
     
     
         13 . A method of treating type II diabetes in a patient comprising administering to said patient a therapeutically effective amount of a compound according to  claim 1 .  
     
     
         14 . A method of making a compound of the formula (I) below:  
       
         
           
           
               
               
           
         
         wherein R 1 , R 2  and R 3  are as defined in  claim 1 , said method comprising:  
         (a) reacting the compound of formula (II), wherein X and X′ are halogens, with an amine R′R″NH, wherein R 2 =—NR′R″, in the presence of a base to form a compound of formula (III):  
         
           
             
             
                 
                 
             
           
         
         (b) reacting the compound of formula (III) with an amine R 1 NH 2  to form the compound of formula (I):  
         
           
             
             
                 
                 
             
           
         
       
     
     
         15 . A method of making a compound of the formula (I) below:  
       
         
           
           
               
               
           
         
         wherein R 1  and R 2  are as defined in  claim 1  and R 3  is NO 2 , said method comprising:  
         (a) reacting the compound of formula (II), wherein X and X′ are halogens, with a thiocyanate salt to produce a compound of formula (VI):  
         
           
             
             
                 
                 
             
           
         
         (b) reacting the compound of formula (VI) with R 1 NH 2  in the presence of a base to provide the compound of formula (VII):  
         
           
             
             
                 
                 
             
           
         
         (c) reacting the compound of formula (VII) with an amine R′R″NH, wherein R 2 =—NR′R″, to provide the compound of formula (I):