3-Deoxypentopyranosyl nucleic acid, its production and its use

Abstract

The invention relates to a 3′-deoxypentopyranosylnucleic acid consisting essentially of 3′-deoxypentopyranosylnucleosides of the formulae (I) or of the formulae (II) their preparation and use for the production of a therapeutic, diagnostic and/or electronic component.

1 . A conjugate according to the following structure:  
       
         
           
           
               
               
           
         
         wherein A is selected from the group consisting of DNA, RNA, peptide, protein, antibody, functional antibody fragment, and any other biomolecule; and  
         wherein B is selected from the group consisting of 9-adeninyl, 9-guaninyl, 1-thyminyl, 1-cytosinyl, 1-uracilyl, and 1-indolyl.  
       
     
     
         2 . The conjugate of  claim 1 , wherein the pentopyranosyl nucleotides are in the D configuration.  
     
     
         3 . The conjugate of  claim 1 , wherein the pentopyranosyl nucleotides are in the L configuration.  
     
     
         4 . The conjugate of  claim 1 , wherein the pentopyranosyl nucleotides are selected from the group consisting of ribo-, arabino-, lyxo-, and xylopyranosyl nucleotides.  
     
     
         5 . A conjugate of the structure:  
       
         
           
           
               
               
           
         
         wherein R is H or OH, and  
         wherein B is selected from the group consisting of 9-adeninyl, 9-guaninyl, 1-thyminyl, 1-cytosinyl, 1-uracilyl, and 1-indolyl.  
       
     
     
         6 . The conjugate of  claim 5 , wherein the pentopyranosyl nucleotides are in the D configuration.  
     
     
         7 . The conjugate of  claim 5 , wherein the pentopyranosyl nucleotides are in the L configuration.  
     
     
         8 . The conjugate of  claim 5 , wherein the pentopyranosyl nucleotides are selected from the group consisting of ribo-, arabino-, lyxo-, and xylopyranosyl nucleotides.  
     
     
         9 . A conjugate of the structure:  
       
         
           
           
               
               
           
         
         wherein A is selected from the group consisting of DNA, RNA, peptide, protein, antibody, functional antibody fragment, and any other biomolecule; and  
         wherein B is selected from the group consisting of 9-adeninyl, 9-guaninyl, 1-thyminyl, 1-cytosinyl, 1-uracilyl, and 1-indolyl.  
       
     
     
         10 . The conjugate of  claim 9 , wherein the pentopyranosyl nucleotides are in the D configuration.  
     
     
         11 . The conjugate of  claim 9 , wherein the pentopyranosyl nucleotides are in the L configuration.  
     
     
         12 . The conjugate of  claim 9 , wherein the pentopyranosyl nucleotides are selected from the group consisting of ribo-, arabino-, lyxo-, and xylopyranosyl nucleotides.