Monoclonal antibodies specific to VEGF receptors and uses thereof

Abstract

Monoclonal antibodies that specifically bind to an extracellular domain of a flt-1 receptor and neutralize activation of the receptor are provided. In vitro and in vivo methods of using these antibodies are also provided.

1 - 28 . (Canceled)  
     
     
         29 . A process for preparing a polypeptide that comprises an amino acid sequence that specifically binds to an extracellular domain of a flt-1 receptor and neutralizes activation of the receptor, the process comprising: 
 culturing cells that express a nucleic acid molecule comprising a nucleic acid sequence that encodes an amino acid sequence wherein the amino acid sequence consists of the variable region of a monoclonal antibody that specifically binds to an extracellular domain of a fit-1 receptor and neutralizes activation of the receptor; and    isolating the polypeptide from the cultured cells.    
     
     
         30 - 32 . (Canceled)  
     
     
         33 . A process for preparing a polypeptide that comprises an amino acid sequence that specifically binds to an extracellular domain of a fit-1 receptor and inhibits tumor growth in a mammal, the process comprising: 
 culturing cells that express a nucleic acid molecule comprising a nucleic acid sequence that encodes an amino acid sequence wherein the amino acid sequence consists of the variable region of a monoclonal antibody that specifically binds to an extracellular domain of a fit-1 receptor and inhibits tumor growth in the mammal; and    isolating the polypeptide from the cultured cells.    
     
     
         34 - 52 . (Canceled)