Circovirus sequences associated with piglet weight loss disease (PWD)

Abstract

The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences, and cells and animals transformed by the vectors; methods for detecting the nucleic acids or polypeptides, and kits for diagnosing infection by a PWD circovirus, also are provided; method for selecting compounds capable of modulating the viral infection is further provided; and pharmaceutical, including vaccines, compositions for preventing and/or treating viral infections caused by PWD circovirus and the use of vectors for preventing and/or treating diseases also are provided.

1 . A composition for modulating cellular replication of porcine circovirus type B (PCV-B) comprising a pharmaceutically or veterinarily acceptable vehicle and an active agent comprising a PCV-B immunogen present in an amount effective to modulate cellular replication, wherein said immunogen is an inactivated PCV-B.  
     
     
         2 . The composition of  claim 1 , wherein the immunogen is recombinantly produced.  
     
     
         3 . A method for modulating cellular replication of porcine circovirus type B (PCV-B) in a pig comprising administering to the pig the composition of  claim 1 .  
     
     
         4 . The method of  claim 3 , wherein the immunogen is recombinantly produced.  
     
     
         5 . The method of  claim 3 , wherein the administering is prior to breeding.  
     
     
         6 . The method of  claim 3 , wherein the administering is to a pregnant female pig.  
     
     
         7 . A composition for inhibiting viral replication of porcine circovirus type B (PCV-B) comprising a pharmaceutically or veterinarily acceptable vehicle and an active agent comprising a PCV-B immunogen present in an amount effective to inhibit viral replication, wherein said immunogen is an inactivated PCV-B.  
     
     
         8 . The composition of  claim 7 , wherein the immunogen is recombinantly produced.  
     
     
         9 . A method for inhibiting viral replication of porcine circovirus type B (PCV-B) in a pig comprising administering to the pig the composition of  claim 7 .  
     
     
         10 . The method of  claim 9 , wherein the immunogen is recombinantly produced.  
     
     
         11 . The method of  claim 9 , wherein the administering is prior to breeding.  
     
     
         12 . The method of  claim 9 , wherein the administering is to a pregnant female pig.