Diagnostic agents for pancreatic exocrine function

Abstract

The present invention provides a 13 C-labeled oligosaccharide or polysaccharide or a salt thereof excluding U- 13 C-maltose, 13 C-starch, 1- 13 C-maltotetraose and 1- 13 C -amylose; a derivative of the 13 C-labeled oligosaccharide or polysaccharide or salt thereof; a 13 C-labeled inclusion complex or a salt thereof, which comprises a cyclodextrin or a modified derivative thereof as a host molecule; a 13 C- or 14 C-labeled fluorescein ester compound or a salt thereof; and a diagnostic agents for pancreatic exocrine function comprising these compounds 13 C- or 14 C-labeled.

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         16 . A method of diagnosing pancreatic exocrine function comprising administering a  13 C- or  14 C-labeled oligosaccharide or polysaccharide or a salt thereof or a derivative thereof other than  13 C-starch.  
     
     
         17 . The method according to  claim 16 , wherein the  13 C- or  14 C-labeled oligosaccharide or polysaccharide or salt thereof or derivative thereof is hydrolyzed with α-amylase.  
     
     
         18 . The method according to  claim 17 , wherein the  13 C- or  14 C-labeled oligosaccharide or polysaccharide or salt thereof or derivative thereof is not hydrolyzed with α-glucosidase.  
     
     
         19 . The method according to  claim 16 , wherein the  13 C- or  14 C-labeled oligosaccharide or polysaccharide is a linear or branched oligosaccharide or polysaccharide.  
     
     
         20 . The method according to  claim 19 , wherein the  13 C- or  14 C-labeled oligosaccharide or polysaccharide is modified at the non-reducing terminal.  
     
     
         21 . The diagnostic agent for pancreatic exocrine function according to  claim 16 , wherein the  13 C- or  14 C-labeled oligosaccharide or polysaccharide is a cyclic oligosaccharide or polysaccharide.  
     
     
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         23 . The method according to  claim 16 , wherein the pancreatic exocrine function to be diagnosed is the ability of the pancreas to secrete α-amylase.  
     
     
         24 . The method according to  claim 16 , wherein the pancreatic exocrine function to be diagnosed is the ability of the pancreas to secrete a-amylase and at least one pancreatic exocrine enzyme other than α-amylase.  
     
     
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