Bioadhesive antibacterial wound healing composition

Abstract

A bioadhesive wound-healing composition includes pullulan, pyruvate, an antioxidant, and a mixture of saturated and unsaturated fatty acids. The composition can be provided in the form of a film that does not self-adhere. The composition can include additional medicinal agents, such as polymyxin B sulfate, bacitracin zinc, and neomycin sulfate. Methods for producing the composition and methods for treating wounds with the composition are also disclosed.

1 - 25 . (cancelled)  
     
     
         26 . A bioadhesive film composition wherein said film is a solid film comprising pyruvate, an antioxidant, and a mixture of saturated and unsaturated fatty acids that resuscitate injured mammalian cells.  
     
     
         27 . The composition according to  claim 26 , wherein said film comprises an agent selected from the group consisting from pullulan, polyvinyl alcohol, methylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellulose and carboxymethylcellulose and salts thereof and combinations thereof.  
     
     
         28 . The composition according to  claim 26  further comprising a anesthetic agent.  
     
     
         29 . The composition according to  claim 28 , wherein said anesthetic agent comprises pramoxine hydrochloride.  
     
     
         30 . The composition according to  claim 28 , wherein said anesthetic agent comprises lidocaine.  
     
     
         31 . The composition according to  claim 28 , wherein said anesthetic agent comprises benzocaine.  
     
     
         32 . The composition according to  claim 26 , further comprising an anti-microbial agent.  
     
     
         33 . The composition according to  claim 32 , wherein said anti-microbial agent comprises neomycin sulfate.  
     
     
         34 . The composition according to  claim 32 , wherein said anti-microbial agent comprises bacitracin zinc.  
     
     
         35 . The composition according to  claim 32 , wherein said anti-microbial agent comprises polymyxin B sulfate.  
     
     
         36 . The composition according to  claim 32 , wherein said anti-microbial agent comprises triclosan.  
     
     
         37 . The composition according to  claim 26 , further comprising a scar reducing agent.  
     
     
         38 . The composition according to  claim 37 , wherein said scar reducing agent comprises all forms of vitamin E.  
     
     
         39 . The composition according to  claim 26 , further comprising a pharmaceutically active agent.  
     
     
         40 . The composition according to  claim 39 , wherein said pharmaceutically active is selected from the groups consisting of immunostimulating agents, antiviral agents antikeratolytic agents, anti-inflammatory agent, antifungal agents, tretinoin, sunscreen agents, dermatological agents, topical antihistamine agents, antibacterial agents, other bioadhesive agents, respiratory bursting inhibitors, inhibitors of prostaglandin synthesis, steroidal anti-inflammatory agents, burn relief medications, sun burn medications, acne preparations, insect bite and sting medications, wound cleansers, wound dressings and combinations thereof.  
     
     
         41 . The composition according to  claim 26 , wherein said film is a standalone film.  
     
     
         42 . The composition according to  claim 26 , wherein said film is a solid dried film.  
     
     
         43 . The composition according to  claim 26 , wherein said film is a single layer film.