Laboratory scale milling process

Abstract

There is provided a process for reducing particle size of a drug, the process comprising (a) a step of dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension; (b) a step of bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension; (c) a step of magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 μm; and (d) a step of separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring.

1 - 50 . Delete  
     
     
         51 . A pharmaceutical suspension prepared by a process for reducing particle size of a drug, wherein the process comprises 
 (a) dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension.    (b) bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension;    (c) magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 mm;    (d) separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring; and    (e) diluting the milled suspension with at least one pharmaceutically acceptable excipient to form a pharmaceutical suspension.    
     
     
         52 . A powder blend prepared by a process for reducing particle size of a drug, wherein the process comprises 
 (a) dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension;    (b) bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension;    (c) magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 mm;    (d) separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring;    (e) drying the milled suspension to form a drug powder; and    (f) mixing the drug powder together with one or more excipients to form a powder blend.    
     
     
         53 . A solid dosage form prepared by a process for reducing particle size of a drug, wherein the process comprises 
 (a) dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension;    (b) bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension;    (c) magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 mm;    (d) separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring;    (e) drying the milled suspension to form a drug powder; and    (f) compressing or encapsulating the powder blend to form a solid dosage form.    
     
     
         54 . An imbibable liquid prepared by a process for reducing particle size of a drug, wherein the process comprises 
 (a) dispersing about 10 g or less of the drug in a suitable volume of a liquid dispersion medium to form a suspension;    (b) bringing together in a vessel grinding media, magnetically activatable means for stirring and the suspension;    (c) magnetically activating the means for stirring to effect milling of the suspension to a weight average particle size not greater than about 1 mm;    (d) separating the resulting milled suspension from the grinding media and the magnetically activatable means for stirring;    (e) drying the milled suspension to form a drug powder; and    (f) suspending the drug powder in an inert liquid vehicle to form an imbibable liquid.    
     
     
         55 . The imbibable liquid prepared according to  claim 54  wherein the inert liquid vehicle is water or fruit juice.