Applicator for tissue adhesive

Abstract

An adhesive applicator, for applying medical adhesives, and particularly cyanoacrylates, including a body (20) comprising an internal reservoir ( 22 ) and an opening between the internal reservoir ( 22 ) and the exterior of the body ( 20 ); a sponge ( 26 ) disposed over the opening; a slotted tip nozzle ( 30 ) disposed over the sponge ( 26 ); and a small orifice tip nozzle ( 40 ) disposed over the slotted tip nozzle.( 30 )

1 . An adhesive applicator, comprising: 
 a body comprising an internal reservoir and an opening between the internal reservoir and the exterior of the body;    a sponge disposed over the opening;    a slotted tip nozzle disposed over the sponge; and    a small orifice tip nozzle disposed over the slotted tip nozzle.    
     
     
         2 . The adhesive applicator of  claim 1 , wherein the slotted tip nozzle is releasably attached to the body, thereby covering the sponge.  
     
     
         3 . The adhesive applicator of  claim 1 , wherein the small orifice tip nozzle is releasably attached to the slotted tip nozzle, thereby covering the slotted tip of the slotted tip nozzle.  
     
     
         4 . The adhesive applicator of  claim 1 , wherein the small orifice tip nozzle is releasably attached to the body, thereby covering the slotted tip of the slotted tip nozzle.  
     
     
         5 . The adhesive applicator of  claim 1 , wherein the body is deformable such that squeezing on the body forces contents of the internal reservoir out through the opening in the applicator body.  
     
     
         6 . The adhesive applicator of  claim 1 , further comprising: 
 an adhesive in the internal reservoir.    
     
     
         7 . The adhesive applicator of  claim 6 , wherein the adhesive is a medical adhesive.  
     
     
         8 . The adhesive applicator of  claim 7 , wherein the medical adhesive is a cyanoacrylate ester, in monomeric form, represented by formula I:  
       
         
           
           
               
               
           
         
       
       where R is selected from the group consisting of: 
 alkyl of 1 to 10 carbon atoms,  
 alkenyl of 2 to 10 carbon atoms,  
 cycloalkyl groups of from 5 to 8 carbon atoms,  
 phenyl,  
 2-ethoxyethyl,  
 3-methoxybutyl,  
 and a substituent of the formula:  
                     
  wherein each R′ is independently selected from the group consisting of: 
 hydrogen and methyl, and  
 
 R″ is selected from the group consisting of: 
 alkyl of from 1 to 6 carbon atoms,  
 alkenyl of from 2 to 6 carbon atoms,  
 alkynyl of from 2 to 6 carbon atoms,  
 cycloalkyl of from 3 to 8 carbon atoms,  
 aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl,  
 phenyl, and  
 phenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, alkyl of 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms.  
 
 
     
     
         9 . The adhesive applicator of  claim 1 , wherein the nozzle of the slotted tip nozzle has a width of between ⅓ and ⅔ of the width of the sponge.  
     
     
         10 . A method of closing, sealing and dressing a wound with an adhesive applicator comprising a body with an internal reservoir, adhesive disposed in the internal reservoir and an opening between the internal reservoir and the exterior of the body; a sponge disposed over the opening; a slotted tip nozzle disposed over the sponge; and a small orifice tip nozzle disposed over the slotted tip nozzle; comprising: 
 closing the wound by applying small drops of adhesive to the wound, the small drops being applied by forcing the adhesive from the internal reservoir through the sponge, through the slotted tip nozzle and then through the small orifice tip nozzle;    removing the small orifice tip nozzle;    sealing the wound by applying a line of adhesive with the slotted tip nozzle;    removing the slotted tip nozzle; and    dressing the wound by applying further adhesive with the sponge.    
     
     
         11 . The method of  claim 10 , wherein forcing the adhesive from the internal reservoir through the sponge, through the slotted tip nozzle and then through the small orifice tip nozzle by squeezing on the body of the applicator.  
     
     
         12 . The method of  claim 10 , further comprising: 
 adjusting the width of the line of adhesive applied by the slotted tip nozzle by rotating the applicator, thereby rotating the slotted tip nozzle.    
     
     
         13 . The method of  claim 10 , wherein the adhesive is a medical adhesive.  
     
     
         14 . The adhesive applicator of  claim 13 , wherein the medical adhesive is a cyanoacrylate ester, in monomeric form, represented by formula I:  
       
         
           
           
               
               
           
         
       
       where R is selected from the group consisting of: 
 alkyl of 1 to 10 carbon atoms,  
 alkenyl of 2 to 10 carbon atoms,  
 cycloalkyl groups of from 5 to 8 carbon atoms,  
 phenyl,  
 2-ethoxyethyl,  
 3-methoxybutyl,  
 and a substituent of the formula:  
                     
  wherein each R′ is independently selected from the group consisting of: 
 hydrogen and methyl, and  
 
 R″ is selected from the group consisting of: 
 alkyl of from 1 to 6 carbon atoms,  
 alkenyl of from 2 to 6 carbon atoms,  
 alkynyl of from 2 to 6 carbon atoms,  
 cycloalkyl of from 3 to 8 carbon atoms,  
 aralkyl selected from the group consisting of benzyl, methylbenzyl and phenylethyl,  
 phenyl, and  
 phenyl substituted with 1 to 3 substituents selected from the group consisting of hydroxy, chloro, bromo, nitro, alkyl of 1 to 4 carbon atoms, and alkoxy of from 1 to 4 carbon atoms.