Structural/biological implant system

Abstract

A structural/biological implant and method of use. The implant being utilized as a single or multiple staged system that is designed to encourage new alveolar bone growth with or without the need to obtain autologous bone. The implant has an apical portion that is fastened into existing bone, with the remainder of the implant left outside of existing bone. The exposed portion of the implant may have an external shape or configuration with a variety of attached and/or integrally formed mechanical retention and stability elements. Osteotropic/angiotropic material may be associated with the implant to induce and or conduct new bone growth and possible vascularization, thus, rather than fitting the implant into the bone, the bone is grown integratively with the implant. The osteotropic/angiotropic materials may be simultaneously placed with the staged implant to provide consistent stabilization for the materials and to provide an immediately available surface for bone cell adhesion and growth. The invention thus allows implants to be used in location where the volume and/or shape of the bone would not be adequate for existing implant systems.

1 . An osteointegrative implant comprising: 
 a first implant portion comprising an apical end and an opposing coronal end, said coronal end having a connecting surface, said first implant portion having an embeddable anchor portion proximate the apical end, said first implant portion having an osteointegrative portion with an osteointegrative surface, and    a preliminary stabilizer disposed intermediate the apical end and the coronal end.    
   
   
       2 . The osteointegrative implant of  claim 1 , wherein the preliminary stabilizer is integrally formed with the first implant portion.  
   
   
       3 . The osteointegrative implant of  claim 1 , wherein the osteointegrative portion disposed intermediate the apical end and the coronal end.  
   
   
       4 . The osteointegrative implant of  claim 1 , further comprising an osteotropic/angiotropic stabilizer disposed intermediate the coronal end and the preliminary stabilizer.  
   
   
       5 . The osteointegrative implant of  claim 1 , further comprising a coronal transmucosal portion associated with the connecting surface.  
   
   
       6 . The osteointegrative implant of  claim 1 , further comprising a coronal transmucosal portion associated with the connecting surface wherein the transmucosal portion comprises an integral collar.  
   
   
       7 . The osteointegrative implant of  claim 1 , further comprising an extender removably associated with the connecting surface.  
   
   
       8 . The osteointegrative implant of  claim 1 , wherein the anchor portion is engagable with cortical bone.  
   
   
       9 . The osteointegrative implant of  claim 1 , wherein the osteointegrative portion is configured to modify the formation of biological tissues  
   
   
       10 . The osteointegrative implant of  claim 1 , wherein the osteointegrative portion is configured to release a bone morphogenic protein.  
   
   
       11 . The osteointegrative implant of  claim 1 , wherein the osteointegrative portion is configured to modify endochondral bone formation.  
   
   
       12 . The osteointegrative implant of  claim 1 , wherein the osteointegrative surface is coated with calcium phosphate.  
   
   
       13 . The osteointegrative implant of  claim 1 , wherein the osteointegrative portion is porous.  
   
   
       14 . The osteointegrative implant of  claim 1 , wherein the osteointegrative portion is configured as a carrier for drugs, proteins, or genetic material.  
   
   
       15 . The osteointegrative implant of  claim 1 , wherein the osteointegrative portion is resorbable.  
   
   
       16 . The osteointegrative implant of  claim 1 , further comprising an osteotropic/angiotropic material disposed intermediate the coronal end and the preliminary stabilizer.  
   
   
       17 . The osteointegrative implant of  claim 1 , further comprising an osteotropic/angiotropic material disposed intermediate the coronal end and the preliminary stabilizer wherein the osteotropic/angiotropic material is a scaffold matrix.  
   
   
       18 . The osteointegrative implant of  claim 1 , further comprising an osteotropic/angiotropic material disposed intermediate the coronal end and the preliminary stabilizer wherein the osteotropic/angiotropic material is configured to modulate the bioavailability of osteoactive materials.  
   
   
       19 . The osteointegrative implant of  claim 1 , further comprising a second implant portion, said first implant portion and said second implant portion being connected by an osteotropic/angiotropic material.  
   
   
       20 . The osteointegrative implant of  claim 1 , further comprising a second implant portion, said first implant portion and said second implant portion being connected by a trans-implant element.  
   
   
       21 . The osteointegrative implant of  claim 1 , further comprising a first stage II assembly having a coronal end and an engagement end, said stage II assembly engagement end fixed to the first implant connecting surface, said first stage II assembly having a stage II osteointegrative portion with a stage II osteointegrative surface and having a stage II connecting surface at the stage II coronal end.  
   
   
       22 . The osteointegrative implant of  claim 1 , further comprising a first stage II assembly having a coronal end and an engagement end, said stage II assembly engagement end fixed to the first implant connecting surface, said first stage II assembly having a stage II osteointegrative portion with a stage II osteointegrative surface and having a stage II connecting surface at the stage II coronal end, said stage II connecting surface having a stage II coronal transmucosal portion.  
   
   
       23 . The osteointegrative implant of  claim 1 , further comprising a first stage II assembly having a coronal end and an engagement end, said stage II assembly engagement end fixed to the first implant connecting surface, said stage II assembly having a stage II osteointegrative portion with a stage II osteointegrative surface and having a stage II connecting surface at the stage II coronal end, said stage II assembly having a stage II osteotropic/angiotropic material stabilizer intermediate the stage II coronal end and the engagement end.  
   
   
       24 . The osteointegrative implant of  claim 1 , further comprising a first stage II assembly and a second stage II assembly each stage II assembly having a coronal end and an engagement end, each stage II assembly engagement end fixed to a respective first implant connecting surface, each stage II assembly having a stage II osteointegrative portion with a stage II osteointegrative surface and having a stage II connecting surface at the stage II coronal end, wherein said second stage II assembly and said first stage II assembly are connected by an osteotropic/angiotropic material.  
   
   
       25 . The osteointegrative implant of  claim 1 , further comprising a first stage II assembly and a second stage II assembly each stage II assembly having a coronal end and an engagement end, each stage II assembly engagement end fixed to a respective first implant connecting surface, each stage II assembly having a stage II osteointegrative portion with a stage II osteointegrative surface and having a stage II connecting surface at the stage II coronal end, wherein said second stage II assembly and said first stage II assembly are connected by a trans-implant element.  
   
   
       26 . A method of promoting the growth of new bone tissue comprising: 
 providing an osteointegrative implant comprising a first implant portion comprising an apical end and an opposing coronal end, said coronal end having a connecting surface, said first implant portion having an embeddable anchor portion proximate the apical end, said first implant portion having an osteointegrative portion with an osteointegrative surface, and a preliminary stabilizer disposed intermediate the apical end and the coronal end;    opening a surgical site to exposed existing bone;    engaging the initial implant portion with a tool;    fastening the embeddable anchor portion into the bone to a depth where the preliminary stabilizer engages the bone;    ensuring that the osteointegrative surface is coronal to a surface of existing bone;    disposing an osteotropic material between the surface of existing bone and the coronal end; and    closing the surgical site.    
   
   
       27 . A method of  claim 26 , further comprising; 
 waiting a period of time to allow new bone growth to occur adjacent the first implant portion;    assessing the new bone growth;    reopening the surgical site after assessing the new bone growth;    attaching, to said first implant connecting surface, a transmucosal segment and a prosthetic segment; and    closing the surgical site.    
   
   
       28 . The method of  claim 26 , further comprising; 
 waiting a period of time to allow new bone growth to occur adjacent the first implant portion;    assessing the new bone growth;    reopening the surgical site after assessing the new bone growth;    providing a stage II assembly comprising a coronal end and an engagement end, said first stage II assembly having a stage II osteointegrative portion with a stage II osteointegrative surface and having a stage II connecting surface at the stage II coronal end;    attaching a stage II assembly to the first implant portion, wherein said stage II assembly engagement end is fixed to the first implant connecting surface;    associating an osteotropic material with a portion of the stage II assembly; and    closing the surgical site.    
   
   
       29 . The method of  claim 26 , further comprising; 
 waiting a period of time to allow new bone growth to occur adjacent the first implant portion;    assessing the new bone growth;    reopening the surgical site after assessing the new bone growth;    providing a stage II assembly comprising a coronal end and an engagement end, said first stage II assembly having a stage II osteointegrative portion with a stage II osteointegrative surface and having a stage II connecting surface at the stage II coronal end;    attaching a stage II assembly to the first implant portion, wherein said stage II assembly engagement end is fixed to the first implant connecting surface;    associating an osteotropic material with a portion of the stage II assembly; and    closing the surgical site.    waiting a period of time to allow new bone growth to occur adjacent the stage II assembly;    assessing the new bone growth has occurred adjacent the at least one stage II assembly;    reopening the surgical site after assessing new bone growth;    attaching, to the stage II connecting surface at the stage II coronal end, a transmucosal segment and a prosthetic segment; and    closing the surgical site.    
   
   
       30 . A method of  claim 26 , wherein further comprising associating a trans-implant element between the first implant portion and a second implant portion.