Complex drug delivery composition and method for treating cancer

Abstract

The present invention relates to compositions and methods for producing a complex drug delivery system which specifically targets cancer cells, has an increase in cellular uptake, is cytotoxic, and suppresses antiapoptotic cellular defenses.

1 . A complex drug delivery composition for treating cancer comprising at least two of the following components: 
 a) a suppressor of antiapoptotic cellular defense,    b) an anticancer agent,    c) a cell-surface targeting moiety, or    d) a multifunctional carrier.    
     
     
         2 . The composition of  claim 1 , wherein the suppressor of antiapoptotic cellular defense, anticancer agent, cell-surface targeting moiety, and multifunctional carrier are operably-linked by a scaffold.  
     
     
         3 . The composition of  claim 1 , wherein the multifunctional carrier and cell-surface targeting moiety are the same molecule.  
     
     
         4 . A method for treating cancer comprising administering an effective amount of a composition of  claim 1  so that the signs or symptoms of cancer are reduced.  
     
     
         5 . A method of producing a complex drug delivery composition comprising providing a scaffold and combining the scaffold with the composition of  claim 1  so that a complex drug delivery system is produced.  
     
     
         6 . The method of  claim 5  wherein the composition comprises at least one molecule of the component.  
     
     
         7 . The composition of  claim 5 , wherein the multifunctional carrier and cell-surface targeting moiety are the same molecule.