Compositions and methods for weight management

Abstract

Compositions and methods for promoting weight management are taught by the present invention. Preferably, the methods include the step of administering a composition of bio-active compounds further including 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, and gamma-aminobutyrate. In one presently preferred embodiment of the present invention, the bio-active compounds are extracted from fenugreek seeds. The methods of the present invention preferably include a composition of bio-active compounds with between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids. In presently preferred embodiments of the present invention, methods may work independently of or synergistically with insulin to stimulate the activity of glucose transport receptors located in muscle. More particularly, methods of the present invention may stimulate the activity of glucose transport receptor type 4. In another presently preferred embodiment of the present invention, a method for weight management includes the steps of: (1) performing a weight management analysis on an individual experiencing nutritional and metabolic deficiencies which impact proper metabolism of glucose and carbohydrates; (2) extracting a composition of bio-active compounds from fenugreek; and (3) administering the composition of bio-active compounds from fenugreek in an amount effective to enhance muscle glucose transportation within the body of the individual.

1 . A method for performing weight management on a human or animal, the method comprising the step of administering an effective amount of a composition of bio-active compounds comprising 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, and gamma-aminobutyrate, wherein the composition comprises between about 10% and 90% amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         2 . The method of  claim 1 , further comprising the step of increasing glucose induced insulin levels.  
     
     
         3 . The method of  claim 1 , further comprising the step of enhancing insulin sensitivity.  
     
     
         4 . The method of  claim 1 , further comprising the step of stimulating a glucose transport factor.  
     
     
         5 . The method of  claim 4 , wherein the glucose transport factor comprises glucose transport factor 4.  
     
     
         6 . The method of  claim 1 , wherein the bio-active compounds are extracted from fenugreek seeds ( Trigonella foenum graecum ).  
     
     
         7 . The method of  claim 1 , wherein the step of administering the composition is selected from the group consisting of oral, parenteral, sublingual, topical, transdermal, intramuscular, and inhalation.  
     
     
         8 . The method of  claim 1 , wherein the effective amount of the combination is between about 1 mg and about 9 mg per kg of body weight.  
     
     
         9 . The method of  claim 1 , wherein the effective amount of the combination is between about 1 mg and about 4 mg per kg of body weight.  
     
     
         10 . The method of  claim 1 , wherein the effective amount of the combination is about 4 mg per kg of body weight.  
     
     
         11 . The method of  claim 1 , wherein the composition of bio-active compounds comprises 4-hydroxyisoleucine, glutamate, and aspartate.  
     
     
         12 . The method of  claim 1 , wherein the composition of bio-active compounds comprises 4-hydroxyisoleucine, glutamate, aspartate, and serine.  
     
     
         13 . The method of  claim 1 , wherein the composition of bio-active compounds comprises 4-hydroxyisoleucine, glutamate, aspartate, serine, and alanine.  
     
     
         14 . The method of  claim 1 , wherein the combination of bio-active compounds comprises 4-hydroxyisoleucine, glutamate, aspartate, serine, alanine, and arginine.  
     
     
         15 . The method of  claim 1 , wherein the combination comprises between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         16 . The method of  claim 1 , wherein the composition functions independently of insulin.  
     
     
         17 . The method of  claim 1 , wherein the composition works synergistically with insulin to enhance the transport of glucose into muscle cells.  
     
     
         18 . A method for performing weight management on a human or animal, the method comprising the step of administering an effective amount of a composition of bio-active compounds comprising 4-hydroxyisoleucine, glutamate, and aspartate, wherein the composition comprises between about 10% and 90% amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         19 . The method of  claim 18 , further comprising the step of increasing glucose induced insulin levels.  
     
     
         20 . The method of  claim 18 , further comprising the step of enhancing insulin sensitivity.  
     
     
         21 . The method of  claim 18 , further comprising the step of stimulating a glucose transport factor.  
     
     
         22 . The method of  claim 21 , wherein the glucose transport factor comprises glucose transport factor 4.  
     
     
         23 . The method of  claim 18 , wherein the step of administering the composition is selected from the group consisting of oral, parenteral, sublingual, topical, transdermal, intramuscular, and inhalation.  
     
     
         24 . The method of  claim 18 , wherein the bio-active compounds are extracted from fenugreek seeds ( Trigonella foenum graecum ).  
     
     
         25 . The method of  claim 18 , wherein the composition of bio-active compounds further comprises serine.  
     
     
         26 . The method of  claim 18 , wherein the composition of bio-active compounds further comprises alanine.  
     
     
         27 . The method of  claim 18 , wherein the combination of bio-active compounds further comprises arginine.  
     
     
         28 . The method of  claim 18 , wherein the effective amount of the combination is between about 1 mg and about 9 mg per kg of body weight.  
     
     
         29 . The method of  claim 18 , wherein the effective amount of the combination is between about 1 mg and about 4 mg per kg of body weight.  
     
     
         30 . The method of  claim 18 , wherein the effective amount of the combination is about 4 mg per kg of body weight.  
     
     
         31 . The method of  claim 18 , wherein the combination comprises between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         32 . The method of  claim 18 , wherein the composition functions independently of insulin.  
     
     
         33 . The method of  claim 18 , wherein the composition works synergistically with insulin to enhance the transport of glucose into muscle cells.  
     
     
         34 . A method for performing weight management on a human or animal, the method comprising the step of administering an effective amount of a composition of bio-active compounds comprising 4-hydroxyisoleucine, glutamate, aspartate, serine, alanine, and arginine, wherein the composition comprises between about 10% and 90% amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         35 . The method of  claim 34 , further comprising the step of increasing glucose induced insulin levels.  
     
     
         36 . The method of  claim 34 , further comprising the step of enhancing insulin sensitivity.  
     
     
         37 . The method of claim  38 , further comprising the step of stimulating a glucose transport factor.  
     
     
         39 . The method of  claim 37 , wherein the glucose transport factor comprises glucose transport factor 4.  
     
     
         40 . The method of  claim 34 , wherein the step of administering the composition is selected from the group consisting of oral, parenteral, sublingual, topical, transdermal, intramuscular, and inhalation.  
     
     
         41 . The method of  claim 34 , wherein the bio-active compounds are extracted from fenugreek seeds ( Trigonella foenum graecum ).  
     
     
         42 . The method of  claim 34 , wherein the composition of bio-active compounds further comprises one or more of the amino acids selected from the group consisting of threonine, proline, glycine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, and gamma-aminobutyrate.  
     
     
         43 . The method of  claim 34 , wherein the effective amount of the combination is between about 1 mg and about 9 mg per kg of body weight.  
     
     
         44 . The method of  claim 34 , wherein the effective amount of the combination is between about 1 mg and about 4 mg per kg of body weight.  
     
     
         45 . The method of  claim 34 , wherein the effective amount of the combination is about 4 mg per kg of body weight.  
     
     
         46 . The method of  claim 34 , wherein the combination comprises between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         47 . The method of  claim 34 , wherein the composition functions independently of insulin.  
     
     
         48 . The method of  claim 34 , wherein the composition works synergistically with insulin to enhance the transport of glucose into muscle cells.  
     
     
         49 . A method for performing weight management on a human or animal, the method comprising the step of administering an effective amount of a composition of bio-active compounds comprising 4-hydroxyisoleucine, arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, and gamma-aminobutyrate, wherein the composition comprises between about 10% and 90% amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         50 . The method of  claim 49 , further comprising the step of increasing glucose induced insulin levels.  
     
     
         51 . The method of  claim 49 , further comprising the step of enhancing insulin sensitivity.  
     
     
         52 . The method of  claim 49 , further comprising the step of stimulating a glucose transport factor.  
     
     
         53 . The method of  claim 52 , wherein the glucose transport factor comprises glucose transport factor 4.  
     
     
         54 . The method of  claim 49 , wherein the step of administering the composition is selected from the group consisting of oral, parenteral, sublingual, topical, transdermal, intramuscular, and inhalation.  
     
     
         55 . The method of  claim 49 , wherein the bio-active compounds are extracted from fenugreek seeds ( Trigonella foenum graecum ).  
     
     
         56 . The method of  claim 49 , wherein the effective amount of the combination is between about 1 mg and about 9 mg per kg of body weight.  
     
     
         57 . The method of  claim 49 , wherein the effective amount of the combination is between about 1 mg and about 4 mg per kg of body weight.  
     
     
         58 . The method of  claim 49 , wherein the effective amount of the combination is about 4 mg per kg of body weight.  
     
     
         59 . The method of  claim 49 , wherein the combination comprises between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         60 . The method of  claim 49 , wherein the composition functions independently of insulin.  
     
     
         61 . The method of  claim 49 , wherein the composition works synergistically with insulin to enhance the transport of glucose into muscle cells.  
     
     
         62 . A method for performing weight management on a human or animal, the method comprising the step of: 
 administering an effective amount of a composition of bio-active compounds comprising 4-hydroxyisoleucine and one or more amino acids selected from the group consisting of arginine, aspartate, threonine, serine, glutamate, proline, glycine, alanine, cysteine, valine, methionine, isoleucine, leucine, tryptophan, phenylalanine, ornithine, lysine, histidine, and gamma-aminobutyrate, wherein the composition comprises between about 10% and 90% amino acids and chemical salts, anhydrides, or isomers thereof;    increasing glucose induced insulin levels;    enhancing insulin sensitivity; and    stimulating a glucose transport factor.    
     
     
         63 . The method of  claim 62 , wherein the step of administering the composition is selected from the group consisting of oral, parenteral, sublingual, topical, transdermal, intramuscular, and inhalation.  
     
     
         64 . The method of  claim 62 , wherein the effective amount of the combination is between about 1 mg and about 9 mg per kg of body weight.  
     
     
         65 . The method of  claim 62 , wherein the effective amount of the combination is between about 1 mg and about 4 mg per kg of body weight.  
     
     
         66 . The method of  claim 62 , wherein the effective amount of the combination is about 4 mg per kg of body weight.  
     
     
         67 . The method of  claim 62 , wherein the composition of bio-active compounds comprises 4-hydroxyisoleucine, glutamate, and aspartate.  
     
     
         68 . The method of  claim 62 , wherein the composition of bio-active compounds comprises 4-hydroxyisoleucine, glutamate, aspartate, and serine.  
     
     
         69 . The method of  claim 62 , wherein the composition of bio-active compounds comprises 4-hydroxyisoleucine, glutamate, aspartate, serine, and alanine.  
     
     
         70 . The method of  claim 62 , wherein the combination of bio-active compounds comprises 4-hydroxyisoleucine, glutamate, aspartate, serine, alanine, and arginine.  
     
     
         71 . The method of  claim 62 , wherein the bio-active compounds are extracted from fenugreek seeds ( Trigonella foenum graecum ).  
     
     
         72 . The method of  claim 62 , wherein the combination comprises between about 10% and 70% of 4-hydroxyisoleucine and between about 20% and 40% of the amino acids and chemical salts, anhydrides, or isomers thereof.  
     
     
         73 . The method of  claim 62 , wherein the glucose transport factor comprises glucose transport factor 4.  
     
     
         74 . The method of  claim 62 , wherein the composition functions independently of insulin.  
     
     
         75 . The method of  claim 62 , wherein the composition works synergistically with insulin to enhance the transport of glucose into muscle cells.