Immunogenic peptides of foot-and-mouth disease viruses

Abstract

The present invention relates to FMDC vaccine based on peptides having a sequence of at least 8 amino acids, which corresponds to a partial sequence of the non-structural protein region of FMDV, which was selected by immunoreactivity with FMDV-specific antibodies or by immunoreactivity with FMDV-specific T lymphocytes, and to their production and their use.

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         11 . A peptide consisting of a sequence of 8 to 14 amino acids which corresponds to SEQ ID NO: 48, wherein said peptide has been selected through immunoreactivity with FMDV-specific antibodies or through immunoreactivity with FMDV-specific T lymphocytes.  
     
     
         12 . A peptide consisting of a polypeptide sequence of SEQ ID NO. 48.  
     
     
         13 . A method for detecting FMDV infected animals comprising the steps of; 
 isolating serum from said animal; and    detecting the presence of FMDV antibodies specific for the peptide of SEQ ID NO. 48.    
     
     
         14 . A method for differentiating vaccinated and infected animals comprising the steps of: 
 isolating lymphocytes from a vaccinated or infected animal;    co-incubating the lymphocytes with a peptide of SEQ ID NO. 48; and    detecting one or more responses consisting of lymphocyte proliferation, cytokine production, and cytolytic activity.