Novel heterocycles 3

Abstract

The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.

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         10 . A method of preventing chronic obstructive pulmonary disease, comprising administering to a mammal an effective amount of a compound of formula (I),  
       
         
           
           
               
               
           
         
       
       in which 
 R 1  denotes (C 6 -C 10 )-aryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen (C 1 -C 4 )-alkyl, trifluoromethyl, cyano, nitro and trifluoromethoxy, or 
 denotes (C 1 - 8 )-alkyl, which is optionally substituted by 3- to 10-membered carbocyclyl, or  
 denotes 3- to 10-membered carbocyclyl, which is optionally substituted by identical or different (C 1 -C 4 )-alkyl residues,  
 
 and  
 R 2  denotes 4-tert-butyl-cyclohex-1-yl,  
 or a salt, hydrate or solvate thereof.  
 
     
     
         11 . The method of  claim 10 , wherein R 1  denotes napththyl, or denotes phenyl, which is optionally substituted by identical or different halogen atoms.  
     
     
         12 . The method of  claim 10 , wherein R 2  denotes cis-4-tert-butyl-cyclohex-1-yl.  
     
     
         13 . The method of  claim 10 , wherein the compound is 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-(3-fluorophenyl)imidazo [5,1-f][1,2,4]triazin-4(3H)-one.  
     
     
         14 . The method of  claim 10 , wherein the compound is 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4(3H)-one.  
     
     
         15 . A method of preventing asthma, comprising administering to a mammal an effective amount of a compound of formula (I),  
       
         
           
           
               
               
           
         
       
       wherein 
 R 1  denotes (C 6 -C 10 )-aryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C 1 -C 4 )-alkyl, trifluoromethyl, cyano, nitro and trifluoromethoxy, or 
 denotes (C 1 -C 8 )-alkyl, which is optionally substituted by 3- to 10-membered carbocyclyl, or  
 denotes 3- to 10-membered carbocyclyl, which is optionally substituted by identical or different (C 1 -C 4 )-alkyl residues,  
 
 and  
 R 2  denotes 4-tert-butyl-cyclohex-1-yl,  
 or a salt, hydrate or solvate thereof.  
 
     
     
         16 . The method of  claim 15 , wherein R 1  denotes napththyl, or denotes phenyl, which is optionally substituted by identical or different halogen atoms.  
     
     
         17 . The method of  claim 15 , wherein R 2 denotes cis-4-tert-butyl-cyclohex-1-yl.  
     
     
         18 . The method of  claim 15 , wherein the compound is 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-(3-fluorophenyl)imidazo [5,1-f][1,2,4]triazin-4(3H)-one.  
     
     
         19 . The method of  claim 15 , wherein the compound is 7-(cis-4-tert-butylcyclohexyl)-5-ethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4(3H)-one.