Polynucleotides and polypeptides encoded thereby distantly homologous to heparanase

Abstract

Novel polynucleotides encoding polypeptides distantly homologous to heparanase, nucleic acid constructs including the polynucleotides, genetically modified cells expressing same, recombinant proteins encoded thereby and which may have heparanase or other glycosyl hydrolase activity, antibodies recognizing the recombinant proteins, oligonucleotide's and oligonucleotide analogs derived from the polynucleotides and ribozymes including same.

1 . An isolated nucleic acid comprising a polynucleotide as set forth in SEQ ID NO: 4, said polynucleotide comprises a sequence encoding a polypeptide which comprises a conserved glycosyl hydrolase domain.  
     
     
         2 . A nucleic acid construct comprising the isolated nucleic acid of  claim 1 .  
     
     
         3 . A host cell comprising the nucleic acid construct of  claim 2.