Methods for diagnosis of allergic bronchopulmonary aspergillosis

Abstract

A method for the diagnosis of ABPA in a human individual, comprising determining if the individual carries antibodies reactive with one or more ABPA-related recombinant allergens.

1 - 13 . (canceled)  
     
     
         14 . A method for the diagnosis of ABPA in a human individual, comprising determining if the individual carries antibodies reactive with one or more ABPA-related recombinant allergens which discriminate with 100% specificity between ABPA and allergic sensitization to  A. fumigatus.    
     
     
         15 . The method according to  claim 14 , wherein the allergen is derived from  A. fumigatus.    
     
     
         16 . The method according to  claim 15 , wherein the allergen corresponds to a non-secreted protein from  A. fumigatus.    
     
     
         17 . The method according to  claim 14 , wherein an in vitro immunoassay is carried out on a fluid sample from the individual for the determination of the level of antibodies directed towards said recombinate allergens.  
     
     
         18 . The method according to  claim 17 , wherein antibodies of the IgE class or IgE class, or subclasses thereof, are determined.  
     
     
         19 . The method according to  claim 17 , wherein antibodies of the IgE class are determined.  
     
     
         20 . The method according to  claim 14 , wherein an in vivo test is carried out in the individual.  
     
     
         21 . The method according to  claim 20 , wherein the test is a skin test involving placing said one or more ABPA-related recombinant allergens in the skin of the patient.  
     
     
         22 . The method according to  claim 20 , wherein antibodies of the IgE class or IgE class, or subclasses thereof, are determined.  
     
     
         23 . The method according to  claim 20 , wherein antibodies of the IgE class are determined.