IL-17 like molecules and uses thereof

Abstract

Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.

1 . Isolated nucleic acid having: 
 (a) a nucleic acid sequence encoding amino acid residues 1 to 161 of SEQ ID NO: 2;    (b) a nucleic acid sequence encoding amino acid residues 17 to 161 of SEQ ID NO: 2;    (c) the nucleic acid sequence shown as SEQ ID No: 1;    (d) the nucleic acid sequence from position 159 to 641 of SEQ ID NO: 1; or    (e) the complement of (a), (b), (c) or (d).    
     
     
         2 . The isolated nucleic acid of  claim 1  having a nucleic acid sequence encoding amino acid residues 1 to 161 of SEQ ID NO: 2.  
     
     
         3 . The isolated nucleic acid of  claim 1  having the nucleic acid sequence shown as SEQ ID NO: 1.  
     
     
         4 . The isolated nucleic acid of  claim 1  having the nucleic acid sequence from position 159 to 641 of SEQ ID NO: 1.  
     
     
         5 . The isolated nucleic acid of  claim 1  having a nucleic acid sequence encoding amino acid residues 1 to 161 of SEQ ID NO: 2.  
     
     
         6 . A vector comprising the nucleic acid of  claim 1 .  
     
     
         7 . The vector of  claim 6 , wherein said nucleic acid is operably linked to control sequences recognized by a host cell transformed with the vector.  
     
     
         8 . A host cell comprising the vector of  claim 6 .  
     
     
         9 . The host cell of  claim 8 , wherein said cell is a CHO cell, an  E. coli , a yeast cell or a Baculovirus infected insect cell.  
     
     
         10 . A process for producing an IL-17 like polypeptide, wherein said process comprises culturing the host cell of  claim 8  under conditions suitable for expression of said polypeptide and recovering said polypeptide from the cell culture.