US2005074807A1PendingUtilityA1

Novel gene upregulated in cancers of the prostate

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Assignee: AGENSYS INCPriority: Oct 28, 1999Filed: Oct 5, 2004Published: Apr 7, 2005
Est. expiryOct 28, 2019(expired)· nominal 20-yr term from priority
Inventors:Daniel AfarArthur B. RaitanoRene S. HubertSteven Chappell MitchellAya Jakobovits
C07K 14/47C12N 2799/026A61K 38/00A61P 37/04Y02A50/30
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Claims

Abstract

The present invention relates to a novel protein designated 20P2H8 which shares homology with several heterogeneous nuclear ribonucleoproteins (hnRNPs). A full length approximately 3600 bp 20P2H8 cDNA (SEQ ID NO: 1, encoding a 517 amino acid open reading frame (SEQ ID NO: 2), is provided herein.

Claims

exact text as granted — not AI-modified
1 . A polypeptide comprising SEQ ID NO: 2.  
     
     
         2 . The polypeptide of  claim 1 , wherein the polypeptide is encoded by a polynucleotide that is 90% identical to SEQ ID NO: 1.  
     
     
         3 . The polypeptide of  claim 1 , wherein the polypeptide is encoded by SEQ ID NO: 1.  
     
     
         4 . The polypeptide of  claim 1 , wherein the polypeptide is expressed from an expression vector.  
     
     
         5 . The polypeptide of  claim 4 , wherein the expression vector encodes a coding sequence that is at least 90% identical to SEQ ID NO: 1.  
     
     
         6 . The polypeptide of  claim 1 , wherein the polypeptide is expressed by a host cell.  
     
     
         7 . The polypeptide of  claim 6 , wherein the host cell comprises an expression vector which encodes a coding sequence that is at least 90% identical to SEQ ID NO: 1.  
     
     
         8 . The polypeptide of  claim 6 , wherein the host cell comprises an expression vector which encodes a coding sequence that is SEQ ID NO: 1.  
     
     
         9 . A method of expressing a polypeptide, comprising: 
 providing a host cell which comprises an expression vector encoding a polynucleotide sequence which encodes the polypeptide of SEQ ID NO: 2; and    culturing the host cell under conditions wherein the polypeptide is expressed.    
     
     
         10 . The method of  claim 9 , wherein the polynucleotide is at least 90% identical to SEQ ID NO: 1.  
     
     
         11 . The method of  claim 9 , wherein the polynucleotide is SEQ ID NO: 1.  
     
     
         12 . The method of  claim 9 , further comprising recovering the polypeptide.  
     
     
         13 . The method of  claim 9 , wherein the host cell is a eucaryotic cell.  
     
     
         14 . The method of  claim 13 , wherein the eucaryotic cell is a Chinese Hamster Ovary cell.  
     
     
         15 . The method of  claim 13 , wherein the eucaryotic cell is a yeast cell.  
     
     
         16 . The method of  claim 13 , wherein the eucaryotic cell is a plant cell.  
     
     
         17 . The method of  claim 9 , wherein the host cell is a prokaryotic cell.  
     
     
         18 . The method of  claim 17 , wherein the prokaryotic cell is a bacterial cell.  
     
     
         19 . The method of  claim 18 , wherein the bacterial cell is an  E. coli  cell.  
     
     
         20 . An immunogenic composition comprising a polypeptide of SEQ ID NO: 2.

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