US2005074837A1PendingUtilityA1

Secreted and transmembrane polypeptides and nucleic acids encoding the same

71
Assignee: GENENTECH INCPriority: Sep 15, 2000Filed: May 30, 2002Published: Apr 7, 2005
Est. expirySep 15, 2020(expired)· nominal 20-yr term from priority
Inventors:Kevin BakerMaureen BeresiniLaura DeforgeLuc DesnoyersEllen FilvaroffWei-Qiang GaoMary GerritsenAudrey GoddardPaul GodowskiAustin GurneySteven SherwoodVictoria SmithTimothy StewartDaniel TumasColin WatanabeWilliam I. WoodZemin Zhang
C12N 2799/026C12N 9/00G01N 33/5008C07K 14/70578G01N 33/6845C12Q 1/6886G01N 33/502C12Q 2600/158C07K 2319/30C07K 16/18G01N 33/5061C07K 17/00C12N 15/00G01N 33/68C12Q 1/68G01N 33/5044C12N 9/001C07K 2317/24G01N 2800/042C12Q 2600/136C07K 14/4703C07K 14/00A61K 38/00Y10S530/828C12N 5/06C07K 1/00C12P 21/02Y10S530/866G01N 33/5014G01N 33/505G01N 33/53G01N 33/5011C12P 21/06C07K 2319/00G01N 33/5758G01N 33/575C12N 9/1051C07K 14/4748C07K 14/47C07K 14/705C07K 14/82A61K 39/001102A61K 39/00G01N 2500/00C12N 9/90C07K 14/70546C07K 14/46A61K 39/395A61K 38/17
71
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Claims

Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims

exact text as granted — not AI-modified
1 - 71 . (canceled)  
     
     
         72 . An isolated nucleic acid having at least 80% nucleic acid sequence identity to: 
 (a) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (b) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (e) the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253);    (f) the full-length coding sequence of the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253); or    (g) the full-length coding sequence, of the cDNA deposited under ATCC accession number PTA-861.    
     
     
         73 . The isolated nucleic acid of  claim 72  having at least 85% nucleic acid sequence identity to: 
 (a) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (b) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (e) the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253);    (f) the full-length coding sequence of the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253); or    (g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-861.    
     
     
         74 . The isolated nucleic acid of  claim 72  having at least 90% nucleic acid sequence identity to: 
 (a) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (b) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (e) the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253);    (f) the full-length coding sequence of the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253); or    (g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-861.    
     
     
         75 . The isolated nucleic acid of  claim 72  having at least 95% nucleic acid sequence identity to: 
 (a) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (b) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (e) the nucleic acid sequence shown in  FIG. 253 . (SEQ ID NO:253);    (f) the full-length coding sequence of the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253); or    (g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-861.    
     
     
         76 . The isolated nucleic acid of  claim 72  having at least 99% nucleic acid sequence identity to: 
 (a) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (b) a nucleic-acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (e) the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253);    (f) the full-length coding sequence of the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253); or    (g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-861.    
     
     
         77 . An isolated nucleic acid comprising: 
 (a) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (b) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (e) the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253);    (f) the full-length coding sequence of the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253); or    (g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-861.    
     
     
         78 . The isolated nucleic acid of  claim 77  comprising a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254).  
     
     
         79 . The isolated nucleic acid of  claim 77  comprising a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide.  
     
     
         80 . The isolated nucleic acid of  claim 77  comprising a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254).  
     
     
         81 . The isolated nucleic acid of  claim 77  comprising a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide.  
     
     
         82 . The isolated nucleic acid of  claim 77  comprising the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253).  
     
     
         83 . The isolated nucleic acid of  claim 77  comprising the full-length coding sequence of the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253).  
     
     
         84 . The isolated nucleic acid of  claim 77  comprising the full length coding sequence of the cDNA deposited under ATCC accession number PTA-861.  
     
     
         85 . An isolated nucleic acid that hybridizes to: 
 (a) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (b) a nucleic acid sequence encoding the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254);    (d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in  FIG. 254  (SEQ ID NO:254), lacking its associated signal peptide;    (e) the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253);    (f) the full-length coding sequence of the nucleic acid sequence shown in  FIG. 253  (SEQ ID NO:253); or    (g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-861.    
     
     
         86 . The isolated nucleic acid of  Claim 85 , wherein said hybridization occurs under stringent conditions.  
     
     
         87 . The isolated nucleic acid of  claim 85  which is at least 10 nucleotides in length.  
     
     
         88 . A vector comprising the nucleic acid of  claim 72 .  
     
     
         89 . The vector of  Claim 88 , wherein said nucleic acid is operably linked to control sequences recognized by a host cell transformed with the vector.  
     
     
         90 . A host cell comprising the vector of  claim 88 .  
     
     
         91 . The host cell of  claim 90 , wherein said cell is a CHO cell, an  E. coli  or a yeast cell.

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