Powder of amino acids and method for producing the same

Abstract

Dry powders of amino acids which exhibit great oral meltability and solubility, may be produced by spray drying a hydrous liquid of amino acids to produce a powder of amino acids, where the hydrous liquid of amino acids is prepared into the form of microfine liquid droplets in the presence of trehalose for spray drying, to obtain a powder having a mean particle size of 0.1 μm to 15 μm, as well as granulating and drying during the spray drying or after the spray drying, to obtain a granulated powder having a mean particle size of 20 μm to 1,000 μm.

1 . A method for producing a powder of one or more amino acids, comprising: 
 (1) spray drying a hydrous liquid comprising at least one amino acid to obtain a powder of said at least one amino acid,    wherein said hydrous liquid comprising said at least one amino acids is prepared into the form of microfine liquid droplets in the presence of trehalose for spray drying to obtain a powder having a mean particle size of 0.1 μm to 15 μm.    
     
     
         2 . The method of  claim 1 , wherein said trehalose is added to said hydrous liquid comprising said at least one amino acid.  
     
     
         3 . The method of  claim 1 , wherein said trehalose is prepared into the form of a trehalose solution existing as microfine liquid droplets and is spray dried with said hydrous liquid comprising said at least one amino acid.  
     
     
         4 . The method of  claim 1 , wherein said spray drying is carried out under a condition of an exhaust gas temperature during spray drying of less than 97° C.  
     
     
         5 . The method of  claim 1 , wherein said at least one amino acid is one or more slightly soluble amino acids.  
     
     
         6 . The method of  claim 1 , wherein said at least one amino acid is one or more branched amino acids.  
     
     
         7 . The method of  claim 1 , wherein said hydrous liquid comprising at least one amino acid is a solution.  
     
     
         8 . The method of  claim 1 , wherein said hydrous liquid comprising at least one amino acid is a suspension.  
     
     
         9 . The method of  claim 1 , wherein said hydrous liquid comprising at least one amino acid is an emulsion.  
     
     
         10 . A powder of one or more amino acids, wherein said powder is prepared by a process according to  claim 1 .  
     
     
         11 . A method for producing a powder of one or more amino acids, comprising: 
 (1) spray drying a hydrous liquid comprising at least one amino acid to obtain a powder of said at least one amino acid,    wherein said hydrous liquid comprising at least one amino acid is prepared into the form of microfine liquid droplets in the presence of trehalose for spray drying, and said powder of said at least one amino acid is then granulated and dried, during spray drying or after spray drying, to obtain a granulated powder having a mean particle size of 20 μm to 1,000 μm.    
     
     
         12 . The method of  claim 11 , wherein said trehalose is added to said hydrous liquid comprising at least one amino acid.  
     
     
         13 . The method of  claim 11 , wherein said trehalose is prepared into the form of a trehalose solution existing as microfine liquid droplets and is spray dried and/or a granulated with said hydrous liquid comprising said at least one amino acid.  
     
     
         14 . The method of  claim 11 , wherein said spray drying or granulation is carried out under a condition of an exhaust gas temperature during spray drying of less than 97° C.  
     
     
         15 . The method of  claim 11 , wherein said at least one amino acid is a slightly soluble amino acid.  
     
     
         16 . The method of  claim 11 , wherein said at least one amino acid is a branched amino acid.  
     
     
         17 . The method of  claim 11 , wherein said hydrous liquid comprising at least one amino acid is a solution.  
     
     
         18 . The method of  claim 11 , wherein said hydrous liquid comprising at least one amino acid is a suspension.  
     
     
         19 . The method of  claim 11 , wherein said hydrous liquid comprising at least one amino acid is an emulsion.  
     
     
         20 . A powder of one or more amino acids, wherein said powder is prepared by a process according to  claim 11.