Atopy

Abstract

The present invention relates to isolated nucleic acid sequences of ANGE, CLLD8 and CLLD7 or sequences complementary or substantially homologous thereto or fragments thereof. Also provided are sequences comprising hybrid nucleic add sequences from two or more of the genes. Also provided are nucleic acid expression vectors, polypeptides, antibodies to the polypeptides, host cells, non-human transgenic animals and pharmaceutical compositions and agents. Also provided is the use of the nucleic acid sequence and/or protein in medicine and research, methods for diagnosing or determining predisposition to disease or severity of disease, methods for preventing or treating disease, and kits for use in the methods and the use of the nucleic acid sequence and protein in treating or preventing IgE mediated diseases and non-atopic asthma, and in screens for identifying new agents for use in the methods.

1 . An isolated or recombinant nucleic acid sequence comprising an ANGE mRNA sequence or a sequence complementary or substantially homologous thereto, or a fragment thereof.  
     
     
         2 . An isolated or recombinant nucleic acid sequence comprising a CLLD8 mRNA sequence or a sequence complementary or substantially homologous thereto, or a fragment thereof.  
     
     
         3 . An isolated or recombinant nucleic acid sequence comprising a CLLD7 mRNA sequence or a sequence complementary or substantially homologous thereto, or a fragment thereof.  
     
     
         4 . An isolated or recombinant nucleic acid sequence comprising an ANGE CLLD8 hybrid mRNA sequence or a sequence complementary or substantially homologous thereto, or a fragment thereof.  
     
     
         5 . An isolated or recombinant nucleic acid sequence comprising an ANGE CLLD7 hybrid mRNA sequence or a sequence complementary or substantially homologous thereto, or a fragment thereof.  
     
     
         6 . An isolated or recombinant nucleic acid sequence comprising a CLLD7-CLLD8 hybrid mRNA sequence or a sequence complementary or substantially homologous thereto, or a fragment thereof.  
     
     
         7 . An isolated or recombinant nucleic acid sequence comprising an ANGE-CLLD8-CLLD7 hybrid mRNA sequence or a sequence complementary or substantially homologous thereto, or a fragment thereof.  
     
     
         8 - 86 . (canceled)