US2005089868A1PendingUtilityA1

Modulators of tissue regeneration

52
Priority: May 24, 1996Filed: Sep 4, 2003Published: Apr 28, 2005
Est. expiryMay 24, 2016(expired)· nominal 20-yr term from priority
Inventors:Michele Sanicola-NadelJoseph BonventreCatherine HessionTakaharu IchimuraHenry WeiRichard Cate
A61P 13/12C07K 2319/30A61K 48/00A61K 38/00C07K 2319/00A61K 51/1027A61K 47/6849C07K 14/47G01N 33/5082C07K 16/2803C07K 14/705
52
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Claims

Abstract

Proteins which are upregulated in injured or regenerating tissues, as well as the DNA encoding these proteins, are disclosed, as well as therapeutic compositions and methods of treatment encompassing these compounds.

Claims

exact text as granted — not AI-modified
1 - 20 . (canceled)  
     
     
         21 . An antibody that binds to a polypeptide whose amino acid sequence consists of SEQ ID NO:7.  
     
     
         22 - 36 . (canceled)  
     
     
         37 . The antibody of  claim 21 , wherein the antibody is selected from the group consisting of a humanized monoclonal antibody, a fully human monoclonal antibody, a single chain antibody, a Fab fragment and a chimeric antibody.  
     
     
         38 . The antibody of  claim 21 , wherein the antibody binds to the extracellular domain of the polypeptide whose amino acid sequence consists of SEQ ID NO:7.  
     
     
         39 . An antibody that binds to a polypeptide whose amino acid sequence consists of SEQ ID NO:3.  
     
     
         40 . The antibody of  claim 39 , wherein the antibody binds to the extracellular domain of the polypeptide whose amino acid sequence consists of SEQ ID NO:3.

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