US2005090003A1PendingUtilityA1

P2x7 receptor-deficient non-human animals and uses thereof

Assignee: PFIZER INC UNIVERSITY OF NORTHPriority: Jun 6, 2000Filed: Oct 31, 2003Published: Apr 28, 2005

Est. expiryJun 6, 2020(expired)· nominal 20-yr term from priority

Inventors:Christopher Gabel Beverly Koller

A01K 2227/105C12N 15/8509A01K 67/0276A01K 2267/03C07K 14/705A01K 2267/0312A01K 2217/20A01K 2217/075A01K 2267/0325A01K 2267/0368

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Claims

Abstract

The invention provides non-human, genetically-modified mammals and genetically modified animals cells having a functionally disrupted P 2×7 receptor gene. Also provided are methods for producing genetically modified mice in which one or both P 2×7 R alleles have been functionally inactivated.

Claims

exact text as granted — not AI-modified

1 . A cultured embryonic stem (ES) cell, wherein the genome of said ES cell comprises a homozygous disruption of the P 2×7  receptor, and wherein a cultured macrophage differentiated from said ES cell exhibits a phenotype of reduced ATP-stimulated post-translational processing of interleukin-1α (IL-1α), IL-1β, or IL-18, or reduced ATP-stimulated IL-6 production, or reduced ATP-stimulated intracellular accumulation of macromolecules.  
     
     
         2 . The cultured ES cell of  claim 1 , wherein said cell is human.  
     
     
         3 . The cultured ES cell of  claim 1 , wherein said cell is murine.

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