Medicinal uses of dihydropyrazoles

Abstract

Compounds having a structure according to Formula (I): are effective in a method of increasing erythropoietin and vascularization of tissue in a subject in need thereof.

1 - 14 . (canceled)  
     
     
         15 . A method of increasing vascularization of tissue in a mammalian subject in need of such treatment comprising administering to said subject a safe and effective amount of a compound having the structure:  
       
         
           
           
               
               
           
         
       
       wherein: 
 (a) X is CH; and  
 (b) R6 is selected from the group consisting of nil, methyl, ethyl, methoxy, ethoxy, amino and halo;  
 or an optical isomer, diastereomer or enantiomer, or pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.  
 
     
     
         16 . The method of  claim 15 , wherein the compound is selected from the group consisting of 2-(5-Phenyl-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl)-phenol; 2-(1-Pyridin-2-yl-5-p-tolyl-4,5-dihydro-1H-pyrazol-3-yl)-phenol; 2-[5-(4-Methoxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol; 2-[5-(2-Methoxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol; and 2-[5-(2-hydroxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol.  
     
     
         17 . The method of  claim 16 , wherein the compound is selected from the group consisting of 2-(5-Phenyl-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl)-phenol.  
     
     
         18 . The method of  claim 16 , wherein the compound is selected from the group consisting of 2-(1-Pyridin-2-yl-5-p-tolyl-4,5-dihydro-1H-pyrazol-3-yl)-phenol.  
     
     
         19 . The method of  claim 16 , wherein the compound is selected from the group consisting of 2-[5-(4-Methoxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol.  
     
     
         20 . The method of  claim 16 , wherein the compound is selected from the group consisting of 2-[5-(2-Methoxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol.  
     
     
         21 . The method of  claim 16 , wherein the compound is selected from the group consisting of 2-[5-(2-hydroxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol.  
     
     
         22 . A method of increasing erythropoietin in a mammalian subject in need of such treatment comprising administering to said subject a safe and effective amount of a compound having the structure:  
       
         
           
           
               
               
           
         
       
       wherein: 
 (c) X is CH; and  
 (d) R6 is selected from the group consisting of nil, methyl, ethyl, methoxy, ethoxy, amino and halo;  
 or an optical isomer, diastereomer or enantiomer, or pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof.  
 
     
     
         23 . The method of  claim 22 , wherein the compound is selected from the group consisting of 2-(5-Phenyl-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl)-phenol; 2-(1-Pyridin-2-yl-5-p-tolyl-4,5-dihydro-1H-pyrazol-3-yl)-phenol; 2-[5-(4-Methoxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol; 2-[5-(2-Methoxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol; and 2-[5-(2-hydroxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol.  
     
     
         24 . The method of  claim 23 , wherein the compound is selected from the group consisting of 2-(5-Phenyl-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl)-phenol.  
     
     
         25 . The method of  claim 23 , wherein the compound is selected from the group consisting of 2-(1-Pyridin-2-yl-5-p-tolyl-4,5-dihydro-1H-pyrazol-3-yl)-phenol.  
     
     
         26 . The method of  claim 23 , wherein the compound is selected from the group consisting of 2-[5-(4-Methoxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol.  
     
     
         27 . The method of  claim 23 , wherein the compound is selected from the group consisting of 2-[5-(2-Methoxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol.  
     
     
         28 . The method of  claim 23 , wherein the compound is selected from the group consisting of 2-[5-(2-hydroxy-phenyl)-1-pyridin-2-yl-4,5-dihydro-1H-pyrazol-3-yl]-phenol.