Use of substance P antagonists for the treatment of chronic fatigue syndrome and/or fibromyalgia and use of NK-1 receptor antagonists for the treatment of chronic fatigue syndrome

Abstract

The invention relates to the use of specific substance P antagonists, in particular, 1-acylpiperidine substance P antagonists, especially N-benzoyl-2-benzyl-4-(azanapthoyl-amino)-piperidines, which are unsubsituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoyl, halogen, nitro and trifluoromethyl; and pharmaceutically acceptable salts thereof for treatment of chronic fatigue syndrome (CFS) or for the treatment of fibromyalgia or fibromyalgia associated functional symptoms.

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         4 . A method of treating Chronic Fatigue Syndrome, or fibromyalgia or associated functional symptoms of fibromyalgia comprising administering to a patient in need thereof, a 1-acylpiperidine substance P antagonist or a pharmaceutically acceptable salt thereof.  
     
     
         5 . The method of treatment according to  claim 4 , in which the 1-acylpiperidine is a compound of the formula  
       
         
           
           
               
               
           
         
       
       wherein X and Y are each independently of the other N and/or CH and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl and for each compound, salts thereof.  
     
     
         6 . The method of treatment according to 4, in which the 1-acylpiperidine compound is an N-benzoyl-2-benzyl-4-azanaphthoyl-amino-piperidine compound selected from the group consisting of 
 (2R,4S)-N-[1-(3,5-bisfluoromethyl-benzoyl)-2-(4-chlorobenzyl)-piperidin-4-yl]-4-oxo-4H-1-benzopyran-2-carboxamide;    (2R,4S)-N-[1-(3,5-bisfluoromethyl-benzoyl)-2-benzyl-piperidin-4-yl]-4-oxo-4H-1-benzopyran-2-carboxamide;    (2R,4S)-N-[1-(3,5-bisfluoromethyl-benzoyl)-2-(4-chlorobenzyl)-piperidin-4-yl]-6-fluoro-4-oxo-4H-1-benzopyran-2-carboxamide;    (2R,4S)-N-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-piperidin-4-yl]-quinoline-4-carboxamide;    (2R,4S)-N-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-piperidin-4-yl]-quinazoline-4-carboxamide;    (2R,4S)-N-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-(4-chloro-benzyl)-piperidin-4-yl]-quinoline-4-carboxamide;    (2R,4S)-N-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-(4-chloro-benzyl)-piperidinyl]-quinazoline-4-carboxamide;    (2R,4S)-N-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-(4-chloro-benzyl)-piperidinyl]-isoquinoline-1-carboxamide;    (2R,4S)-N-[1-(3,5-bis-trifluoromethyl-benzoyl)-2-(4-nitro-benzyl)-piperidinyl]-quinazoline-4-carboxamide and for each compound, salts thereof.