Methods and kits for reducing cellular damage, inhibiting free radical production, and scavenging free radicals in mammals

Abstract

Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.

1 . A method of scavenging free radicals in a mammal comprising: 
 administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant; and administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant; wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate.    
     
     
         2 . The method of  claim 1  wherein both the first antioxidant and the second antioxidant comprise acerola concentrate.  
     
     
         3 . The method of  claim 1  wherein only one of the first antioxidant and the second antioxidant comprises acerola concentrate, and the other comprises an antioxidant selected from the group consisting of grape seed extract, pycnogenol, provatene, synthetic β-carotene, natural β-carotene, vitamin E, L-ascorbic acid, □-tocopherol, green tea extract, elderberry extract, lutein, coenzyme Q10, Complex 1, Complex 2, Complex 3, and combinations thereof.  
     
     
         4 . The method of  claim 1  wherein only one of the first antioxidant and the second antioxidant comprises acerola concentrate, and the other comprises an antioxidant selected from the group consisting of grape seed extract, pycnogenol, provatene, green tea extract, elderberry extract, lutein, coenzyme Q10, Complex 1, Complex 2, Complex 3, and combinations thereof.  
     
     
         5 . The method of  claim 1  wherein a first dosage is administered comprised of either the oral dosage form or the topical dosage, a second dosage is administered comprised of the remaining oral dosage or topical dosage not used in the first dosage, and the second dosage is administered at any time during the metabolism of the first dosage.  
     
     
         6 . The method of  claim 1  wherein the administering of the oral dosage form and the administering of the topical dosage form occur within a time frame of about 30 minutes.  
     
     
         7 . The method of  claim 1  wherein the oral dosage form is selected from the group consisting of a pill, capsule, gelcap, geltab, beverage, chewing gum, chewable tablet, lozenge, viscous gel, troche, toothpaste, gargling gel, mouth rinse, and combinations thereof.  
     
     
         8 . The method of  claim 1  wherein the oral dosage form is selected from the group consisting of a pill, capsule, gelcap, geltab, chewable tablet, lozenge, troche, and combinations thereof.  
     
     
         9 . The method of  claim 1  wherein the topical dosage form is selected from the group consisting of an emulsion, solution, dispersion, gel, soap, transdermal patch, and combinations thereof.  
     
     
         10 . The method of  claim 1  wherein the topical dosage form is a lotion.  
     
     
         11 . The method of  claim 1  wherein each of the administering of the oral dosage form and the administering of the topical dosage form is repeated at least twice daily.  
     
     
         12 . The method of  claim 11  wherein both the first antioxidant and the second antioxidant comprise acerola concentrate, and wherein the therapeutically effective amount of acerola concentrate in the oral dosage form is between about 50 mg and about 2000 mg.  
     
     
         13 . The method of  claim 11  wherein both the first antioxidant and the second antioxidant comprise acerola concentrate, and wherein therapeutically effective amount of acerola concentrate in the oral dosage form is between about 350 mg and about 1500 mg.  
     
     
         14 . The method of  claim 11  wherein both the first antioxidant and the second antioxidant comprise acerola concentrate, and wherein the therapeutically effective amount of acerola concentrate in the topical dosage form is between about 15 mg and about 200 mg.  
     
     
         15 . The method of  claim 11  wherein both the first antioxidant and the second antioxidant comprise acerola concentrate, and wherein the therapeutically effective amount of acerola concentrate in the topical dosage form is between about 25 mg and about 100 mg.  
     
     
         16 . A method of inhibiting free radical production in a mammal comprising: administering to the mammal an oral dosage form comprising acerola concentrate; and administering to the mammal a topical dosage form comprising acerola concentrate.  
     
     
         17 . The method of  claim 16  wherein the acerola concentrate in the oral dosage form is provided in an amount of between about 400 mg and about 1200 mg, and the acerola concentrate in the topical dosage form is provided in an amount of between about 50 mg and about 75 mg.  
     
     
         18 . A method of reducing cellular damage in a mammal comprising: administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant; and administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant; wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate, and the administering of the oral dosage form and the administering of the topical dosage form occur within a time frame of about 24 hours.  
     
     
         19 . A kit for reducing cellular damage in a mammal comprising: an oral dosage form comprising a therapeutically effective amount of a first antioxidant; and a topical dosage form comprising a therapeutically effective amount of a second antioxidant; wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate.  
     
     
         20 . The method of  claim 19  wherein both the first antioxidant and the second antioxidant comprise acerola concentrate.