Protected active compound formulations of amino acids and process for their preparation

Abstract

Active compound formulations for animal nutrition of amino acids, vitamins, enzymes and pigments, which are suitable for providing the active compounds in protected form for the nutrition of stock animals, in particular ruminants, and a process for the preparation of these protected active compound formulations.

1 . An active compound formulation protected by a coating, which comprises as the active compound an amino acid or salt thereof, having a particle diameter of less than 1000 μm, and which is coated with a protective shell, and having delayed release properties.  
     
     
         2 . The active compound formulation as claimed in  claim 1 , wherein the active compound is present in the form of crystals or granules.  
     
     
         3 . The active compound formulation as claimed in  claim 1 , which is present in the form of platelet-shaped particles or platelet-shaped crystals, or round crystals.  
     
     
         4 . The active compound formulation as claimed in  claim 2 , which is present in platelet-shaped particles or platelet-shaped crystals, or round crystals.  
     
     
         5 . The active compound formulation as claimed in  claim 2 , wherein the active compound is methionine in the form of crystals, granules or spray granules.  
     
     
         6 . The active compound formulation as claimed in  claim 2 , wherein the active compound is a methionine salt in the form of crystals, granules or spray granules which are suitable for feedstuffs.  
     
     
         7 . The active compound formulation as claimed in  claim 6 , wherein the methionine salt is a Na, K, Ca, Mg, or Zn methioninate in pure or mixed form.  
     
     
         8 . The active compound formulation as claimed in  claim 1 , wherein the protective shell comprises a single coating material and is coated by one-layer application.  
     
     
         9 . The active compound formulation as claimed in  claim 2 , wherein the protective shell comprises a single coating material and is coated by one-layer application.  
     
     
         10 . The active compound formulation as claimed in  claim 3 , wherein the protective shell comprises a single coating material and is coated by one-layer application.  
     
     
         11 . The active compound formulation as claimed in  claim 4 , wherein the protective shell comprises a single coating material and is coated by one-layer application.  
     
     
         12 . The active compound formulation as claimed in  claim 6 , wherein the protective shell comprises a layer of natural or synthetic polymer.  
     
     
         13 . The active compound formulation as claimed in  claim 12 , wherein the protective shell comprises a layer of a member selected from the group consisting of cellulose esters, ethers, acrylates, poly(meth)acrylates, polyamides, polyesters, copolymers of acrylonitrile, styrene, ethylene, propylene, butadiene, esters of methacrylic acid, esters of acrylic acid, amides of methacrylic acid and amides of acrylic acid.  
     
     
         14 . The active compound formulation as claimed in  claim 8 , wherein the protective shell comprises cellulose ether.  
     
     
         15 . The active compound formulation as claimed in  claim 13 , wherein the protective shell comprises ethylcellulose.  
     
     
         16 . The active compound formulation as claimed in  claim 1 , wherein the amount of the protective shell is 4-30 wt. %, based on total weight of formulation.  
     
     
         17 . The active compound formulation as claimed in  claim 15 , wherein the amount of the protective shell is 5-20 wt. %, based on total weight of formulation.  
     
     
         18 . The active compound formulation as claimed in  claim 1 , wherein the particle diameters are in the range of between 100 and 1000 μm.  
     
     
         19 . The active compound formulation as claimed in  claim 17 , wherein the particle diameters are in the range of between 200 and 800 μm.  
     
     
         20 . The active compound formulation as claimed in  claim 17 , wherein the particle diameter is between 400 and 600 μm.  
     
     
         21 . The active compound formulation as claimed in  claim 1 , which has protection rates in the in vitro release test after 6 h of 60-90%, and after 6-24 h of 10-60% after 24 h.  
     
     
         22 . The active compound formulation as claimed in  claim 20 , which have protection rates in the in vitro release test after 6 h of 75-85%, and after 6-24 h of 35-50% after 24 h.  
     
     
         23 . A process for the preparation of a protected active compound by coating, which comprises coating the active compound having a particle diameter of less than 1000 μm with a protective shell of a coating material which is a natural or synthetic polymer by fluidized bed coating or coacervation, and recovering a coated product with a particle diameter of a maximum of 1000 μm.  
     
     
         24 . The process according to  claim 23 , wherein the polymer is a member selected from the groups consisting of cellulose esters, ethers, acrylates, poly(meth)acrylates, polyamides, polyesters, copolymers of acrylonitrile, styrene, ethylene, propylene, butadiene, esters of methacrylic acid, esters of acrylic acid, amides of methacrylic acid and amides of acrylic acid.  
     
     
         25 . The process as claimed in  claim 23 , wherein the active compound is methionine in the form of crystalline or granulate particles.  
     
     
         26 . The process as claimed in  claim 23 , wherein the active compound is methionine in the form of platelet-shaped particles or platelet-shaped crystals, round crystals, granules or spray granules of a methionine salt which is suitable for feedstuffs use.  
     
     
         27 . The process as claimed in  claim 24 , wherein the active compound is methionine in form of crystalline or granulate particles.  
     
     
         28 . A process as claimed in  claim 26 , wherein methionine salt is Na, K, Ca, Mg, Zn methioninate in pure or mixed form.  
     
     
         29 . The process as claimed in  claim 26 , wherein the protective shell comprises a single coating material and is applied by one-layer application.  
     
     
         30 . The process as claimed in  claim 26 , wherein the protective shell comprises ethylcellulose.  
     
     
         31 . A process for providing nutrition for ruminants comprising feeding the ruminate the active compound formulation of  claim 1 .  
     
     
         32 . A feedstuff for ruminants comprising ruminant feed and the active compound formulation of  claim 1 .  
     
     
         33 . Coated methionine containing particles protected by a coating, which comprises as the active compound a methionine or salt thereof, provided with a protective shell, having a particle diameter of less than 1000 μm, and delayed release properties.  
     
     
         34 . The coated methionine particles as claimed in  claim 33 , wherein the active compound is present in the form of crystals or granules.  
     
     
         35 . The coated methionine particles as claimed in  claim 33 , which is present in platelet-shaped particles or crystals, or round crystals.  
     
     
         36 . The coated methionine particles as claimed in  claim 34 , wherein the active compound is in the form of crystals, granules or spray granules of methionine salts which are suitable for feedstuffs use.  
     
     
         37 . The coated methionine particles as claimed in  claim 36 , wherein the salts are Na, K, Ca, Mg or Zn salts.  
     
     
         38 . Coated methionine particles as claimed in  claim 36 , wherein the protective shell comprises a layer of cellulose esters, ethers, acrylates, poly(meth)acrylates, polyamides, polyesters or copolymers of acrylonitrile, styrene, ethylene, propylene, butadiene, or esters and amides of methacrylic acid or acrylic acid.  
     
     
         39 . Coated methionine particles as claimed in  claim 36 , wherein the protective shell comprises a natural or synthetic polymer.  
     
     
         40 . Coated methionine particles as claimed in  claim 38 , wherein the protective shell comprises ethylcellulose or cellulose.  
     
     
         41 . Coated methionine particles as claimed in  claim 33 , wherein the amount of the protective shell is 4-30 wt. %, based on the end product.  
     
     
         42 . Coated methionine particles as claimed in  claim 33 , wherein the particle diameters are in the range of from 100 to 1000 μm.  
     
     
         43 . Coated methionine particles as claimed in  claim 42 , wherein the particle diameters are in the range of from 200 to 800 μm.  
     
     
         44 . Coated methionine particles as claimed in  claim 42 , wherein the particle diameters are in the range of from 400 to 600 μm.  
     
     
         45 . Coated methionine particles as claimed in  claim 33 , which has protection rates in the in vitro release test after 6 h of 60-90%, and after 6-24 h of 10-60% after 24 h.  
     
     
         46 . Coated methionine particles as claimed in  claim 44 , which has protection rates in the in vitro release test after 6 h of 75-85%, and after 6-24 h of 35-50% after 24 h.