US2005107406A1PendingUtilityA1

Angiogenesis inhibitors

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Assignee: YUNG SHIN PHARMACEUTICAL INDPriority: Mar 29, 2002Filed: Dec 10, 2004Published: May 19, 2005
Est. expiryMar 29, 2022(expired)· nominal 20-yr term from priority
Inventors:Che-Ming TengSheng-Chu KuoFang-Yu LeeShiow-Lin PanJih-Hwa Guh
A61P 9/00A61P 3/10A61P 3/06A61P 9/10A61P 35/00A61P 3/04A61P 27/02A61P 3/00A61P 29/00A61P 1/04A61P 19/02A61K 31/4162A61P 15/00A61K 31/519A61K 31/416A61K 31/4745A61P 17/06
53
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Claims

Abstract

A method for treating an angiogenesis-related disorder. The method includes administrating to a subject in need thereof an effective amount of a compound of the formula: Each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl; each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR′, (CH 2 ) m OR, (CH 2 ) m SR, (CH 2 ) m NRR′, (CH 2 ) m CN, (CH 2 ) m C(O)OR, (CH 2 ) m CHO, (CH 2 ) m CH═NOR, or R 1 and R 2 together, R 3 and R 4 together, or R 5 and R 6 together are O(CH 2 ) m O, in which each of R and R′, independently, is H or C 1 ˜C 6 alkyl; and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.

Claims

exact text as granted — not AI-modified
1 - 15 . (canceled)  
     
     
         16 . A method for treating cancer, comprising administrating to a subject in need thereof an effective amount of a compound of the formula:  
       
         
           
           
               
               
           
         
       
       wherein 
 each of Ar 1 , Ar 2 , and Ar 3 , independently, is phenyl, thienyl, furyl, pyrrolyl, pyridinyl, or pyrimidinyl;  
 each of R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , independently, is R, nitro, halogen, C(O)OR, C(O)SR, C(O)NRR′, (CH 2 ) m OR, (CH 2 ) m SR, (CH 2 ) m NRR′, (CH 2 ) m CN, (CH 2 ) m C(O)OR, (CH 2 ) m CHO, (CH 2 ) m CH═NOR, or R 1  and R 2  together, R 3  and R 4  together, or R 5  and R 6  together are O(CH 2 ) m O, in which each of R and R′, independently, is H or C 1 ˜C 6  alkyl; and m is 0, 1, 2, 3, 4, 5, or 6, and n is 0, 1, 2, or 3.  
 
     
     
         17 . The method of  claim 16 , wherein Ar 1  is phenyl.  
     
     
         18 . The method of  claim 17 , wherein Ar 2  is furyl.  
     
     
         19 . The method of  claim 18 , wherein Ar 2  is 5′-furyl.  
     
     
         20 . The method of  claim 19 , wherein Ar 3  is phenyl.  
     
     
         21 . The method of  claim 20 , wherein each of R 1 , R 2 , R 5 , and R 6  is H.  
     
     
         22 . The method of  claim 21 , wherein n is 1.  
     
     
         23 . The method of  claim 22 , wherein one of R 3  and R 4  is substituted at position 2 of furyl.  
     
     
         24 . The method of  claim 23 , wherein one of R 3  and R 4  is H, and the other is CH 2 OH.  
     
     
         25 . The method of  claim 16 , wherein Ar 2  is furyl.  
     
     
         26 . The method of  claim 25 , wherein Ar 2  is 5′-furyl.  
     
     
         27 . The method of  claim 26 , wherein one of R 3  and R 4  is substituted at position 2 of furyl.  
     
     
         28 . The method of  claim 16 , wherein Ar 3  is phenyl.  
     
     
         29 . The method of  claim 28 , wherein n is 1.  
     
     
         30 . The method of  claim 16 , wherein the cancer is lung cancer.  
     
     
         31 . The method of  claim 30 , wherein Ar 1  is phenyl.  
     
     
         32 . The method of  claim 31 , wherein Ar 2  is furyl.  
     
     
         33 . The method of  claim 32 , wherein Ar 2  is 5′-furyl.  
     
     
         34 . The method of  claim 33 , wherein Ar 3  is phenyl.  
     
     
         35 . The method of  claim 34 , wherein each of R 1 , R 2 , R 5 , and R 6  is H.  
     
     
         36 . The method of  claim 35 , wherein n is 1.  
     
     
         37 . The method of  claim 36 , wherein one of R 3  and R 4  is substituted at position 2 of furyl.  
     
     
         38 . The method of  claim 37 , wherein one of R 3  and R 4  is H, and the other is CH 2 OH.  
     
     
         39 . The method of  claim 30 , wherein Ar 2  is furyl.  
     
     
         40 . The method of  claim 39 , wherein Ar 2  is 5′-furyl.  
     
     
         41 . The method of  claim 40 , wherein one of R 3  and R 4  is substituted at position 2 of furyl.  
     
     
         42 . The method of  claim 30 , wherein Ar 3  is phenyl.  
     
     
         43 . The method of  claim 42 , wherein n is 1.

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