Phorboxazole derivatives for treating cancer

Abstract

Synthetic Phorboxazole A and derivatives thereof for the treatment of cancer, including inhibition of cancer cell growth, induction of apoptosis, and inhibition of metastises.

1 . A composition comprising an effective therapeutic amount of the compound of the formula:  
       
         
           
           
               
               
           
         
       
       and a pharmaceutically acceptable carrier  
     
     
         2 . A composition comprising an effective therapeutic amount of the compound of the formula:  
       
         
           
           
               
               
           
         
       
       and a pharmaceutically acceptable carrier  
     
     
         3 . The composition of  claim 1 , wherein said compound is formulated as a prodrug.  
     
     
         4 . A method for inducing apoptosis cancer cells, said method comprising contacting cancer cells with an effective apoptosis-inducing amount of a compound of  claim 1 .  
     
     
         5 . A method for inhibiting cancer cell division, said method comprising contacting cancer cells with an effective inhibitory dose of a compound of  claim 1 .  
     
     
         6 . A method for treating cancer comprising administering to a patient an effective therapeutic dose of a compound of  claim 1 .  
     
     
         7 . A composition comprising a therapeutically effective dose of one or more of: 29-phorboxamnide A, 31-methyl-phorboxylate, and 18-methyl-phorboxylate and a pharmaceutically acceptable carrier.  
     
     
         8 . A method for preventing adhesion or migration of cancer cells, said method comprising contacting cancer cells with the composition of  claim 7 .  
     
     
         9 . A composition comprising an effective therapeutic dose of synthetic phorboxazole A having the formula (I) and a pharmaceutically acceptable carrier.  
     
     
         10 . A method for inducing apoptosis of cancer cells, comprising administering to the cancer cells an effective dose of synthetic phorboxazole A.  
     
     
         11 . A method for treating cancer comprising administering to a patient an effective therapeutic amount of a compound selected from synthetic Phorboxazole A; 29-phorboxamide A; 31-methyl-phorboxylate; and 18-methyl-phorboxylate.  
     
     
         12 . The composition of  claim 2 , wherein said compound is formulated as a prodrug.  
     
     
         13 . A method for inducing apoptosis cancer cells, said method comprising contacting cancer cells with an effective apoptosis-inducing amount of a compound of  claim 2 .  
     
     
         14 . A method for inhibiting cancer cell division, said method comprising contacting cancer cells with an effective inhibitory dose of a compound of  claim 2 .  
     
     
         15 . A method for treating cancer comprising administering to a patient an effective therapeutic dose of a compound of  claim 2.