Combinatorial strategies for polymer synthesis

Abstract

A method and device for forming large arrays of polymers on a substrate ( 401 ). According to a preferred aspect of the invention, the substrate is contacted by a channel block ( 407 ) having channels ( 409 ) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage ( 403 ), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.

1 . A method of forming polymers having diverse monomer sequences on a single substrate, said substrate comprising a surface with a plurality of selected regions, said method comprising the steps of: 
 a) forming a plurality of channels adjacent said surface, said channels at least partially having a wall thereof defined by a portion of said selected regions;    b) placing selected monomers in said channels to synthesize polymers at said portion of said selected regions, said portion of said selected regions comprising polymers with a sequence of monomers different from polymers in at least one other of said selected regions; and    c) repeating steps a) and b) with said channels formed along a second portion of said selected regions.    
     
     
         2 - 47 . (canceled)