Novel microorganism Pediococcus pentosaceus EROM101, having immune enhancement, anticancer and antimicrobial activities

Abstract

The present invention relates to a novel Pediococcus genus microorganism and more particularly, Pediococcus pentosaceus EROM101 (KCCM-10517) originated from human intestines having immune enhancement, anticancer and antiviral activities and a use thereof. Due to its excellent immune enhancement, anticancer and antimicrobial activities by activating macrophages/spleen cells and inducing gut immunity, the Pediococcus pentosaceus EROM101 of the present invention can be effectively used for the production of various products such as immune enhancement agent, anticancer agent, antimicrobial agent, food additive, intestinal function-controlling agent, live bacterial agent, feed additive and other fermented products.

1 . A biologically pure culture of a microorganism  Pediococcus pentosaceus  EROM101 (Accession number: KCCM-10517), or a mutant or variant thereof having the same immune enhancement, anticancer and antimicrobial activities as the said microorganism.  
     
     
         2 . A composition for immune enhancement agent containing the biologically pure culture of  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1 .  
     
     
         3 . A composition for anticancer agent containing the biologically pure culture of  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1 .  
     
     
         4 . A composition for antimicrobial agent containing the biologically pure culture of  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1 .  
     
     
         5 . A composition for intestinal function-controlling agent containing the biologically pure culture of  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1 .  
     
     
         6 . A composition for live bacterial agent containing the biologically pure culture of  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1 .  
     
     
         7 . A composition for feed additive containing the biologically pure culture of  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1 .  
     
     
         8 . A composition for food additive containing the biologically pure culture of  Pediococcus pentosoceus  EROM101, or mutant or variant thereof of  claim 1 .  
     
     
         9 . A fermented product containing the biologically pure culture of  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1 .  
     
     
         10 . A method for culturing the  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1 , wherein the  Pediococcus pentosaceus  EROM101, or mutant or variant thereof is cultured in a medium consisting of carbon source, nitrogen source, vitamin and mineral at 30-45° C. for 10-40 hours.  
     
     
         11 . A method for enhancing immunity in a subject comprising administering an effective amount of a biologically pure culture of the  Pediococcus pentosaceus  EROM 101, or mutant or variant thereof of  claim 1  to a subject.  
     
     
         12 . A method for treating cancer in a subject comprising administering an effective amount of a biologically pure culture of the  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1  to a subject.  
     
     
         13 . A method for treating microbial infection in a subject comprising administering an effective amount of a biologically pure culture of the  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1  to a subject.  
     
     
         14 . A method for controlling the microbial growth comprising contacting the  Pediococcus pentosaceus  EROM101, or mutant or variant thereof of  claim 1  with other microorganisms.