US2005130304A1PendingUtilityA1

Regulation of endogenous gene expression in cells using zinc finger proteins

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Assignee: SANGAMO BIOSCIENCES INCPriority: Jan 12, 1999Filed: Nov 12, 2004Published: Jun 16, 2005
Est. expiryJan 12, 2019(expired)· nominal 20-yr term from priority
Inventors:George N. Cox, IiiCasey C. CaseStephen P. EisenbergEric JarvisSharon Kaye Spratt
A61P 7/06A61P 9/10A61P 3/06A61P 37/00A61P 9/00A61P 7/00A61P 43/00A61P 29/00A61P 27/02A61P 31/00A61P 31/10A61P 35/00A61P 31/04A61P 31/12A61P 31/18A61P 33/02A61P 25/28C07K 14/52A01K 67/0275C07K 2319/71A61P 17/06A61P 21/04A01K 2217/05C07K 14/47C12N 2830/005C12Q 1/66A61K 48/005C12N 15/63C12N 2830/002A61P 11/00A61P 19/02C12N 15/67C12N 2830/008C12N 2830/85G01N 33/5091A61K 48/00C12N 15/85A61P 21/00C07K 2319/81C12Q 1/6897C07K 2319/00C12N 15/8216
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Claims

Abstract

The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.

Claims

exact text as granted — not AI-modified
1 . A cell comprising an engineered zinc finger protein, wherein the zinc finger protein further comprises an integrase or a functional fragment thereof.  
     
     
         2 . The cell of  claim 1 , wherein the cell is a plant cell.  
     
     
         3 . The cell of  claim 1 , wherein the cell is an animal cell.  
     
     
         4 . The cell of  claim 3 , wherein the cell is a mammalian cell.  
     
     
         5 . The cell of  claim 4 , wherein the cell is a human cell.  
     
     
         6 . The cell of  claim 5 , wherein the cell is a stem cell.  
     
     
         7 . The cell of  claim 6 , wherein the cell is a hematopoietic stem cell.

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