Neisseria spp. polypeptide, nucleic acid sequence and uses thereof

Abstract

The invention discloses the Neisseria spp. NGSP polypeptide, polypeptides derived therefrom (NGSP-derived polypeptides), nucleotide sequences encoding said polypeptides, and antibodies that specifically bind the NGSP polypeptide and/or NGSP-derived polypeptides. Also disclosed are prophylactic or therapeutic compositions, including antigenic, preferably immunogenic compositions, e.g., vaccines, comprising NGSP polypeptide and/or a NGSP-derived polypeptide or antibodies thereto. The invention additionally discloses methods of inducing an immune response to Neisseria and Neisseria NGSP polypeptide and an NGSP-derived polypeptide in animals.

1 - 41 . (canceled)  
     
     
         42 . An isolated nucleic acid comprising the nucleotide sequence of SEQ ID NO: 5.  
     
     
         43 . An isolated nucleic acid that hybridizes under high stringency conditions to a nucleic acid comprising the complement of SEQ ID NO: 5 and that encodes a polypeptide which is recognized by an antibody that specifically binds a polypeptide having amino acid sequence of SEQ ID NO:6.  
     
     
         44 . An isolated nucleic acid comprising a nucleotide sequence encoding a polypeptide which comprises the amino acid sequence of SEQ ID NO: 6 or SEQ ID NO: 7 or a sequence greater than 80% identical to SEQ ID NO: 6 or SEQ ID NO; 7, wherein said polypeptide is recognized by an antibody that specifically binds a polypeptide having amino acid sequence of SEQ ID NO: 6 or SEQ ID NO-7.  
     
     
         45 . A recombinant expression vector comprising the nucleic acid molecule of any one of claims  42 - 44 .  
     
     
         46 . A host cell transformed with the recombinant vector of  claim 45.