US2005148575A1PendingUtilityA1

Compounds and their uses

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Assignee: GUILFORD PHARM INCPriority: Dec 1, 2000Filed: Feb 28, 2005Published: Jul 7, 2005
Est. expiryDec 1, 2020(expired)· nominal 20-yr term from priority
A61P 37/02A61P 9/10A61P 7/00A61P 9/08A61P 9/00A61P 3/10A61P 43/00A61P 25/00A61P 35/00A61P 31/04A61P 27/02A61P 3/00A61P 29/00A61P 31/18A61P 25/16A61P 25/04A61P 25/28A61P 25/02A61P 19/02A61P 19/10A61P 19/06A61P 21/00A61K 31/551C07D 487/06A61P 13/12A61P 1/00C07D 495/06A61P 1/04C07D 471/04A61K 31/55
58
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Claims

Abstract

This invention relates to compounds, pharmaceutical compositions, and methods of using the disclosed compounds for inhibiting PARP.

Claims

exact text as granted — not AI-modified
1 . A compound of the formula:  
       
         
           
           
               
               
           
         
       
       where 
 B is S, SO or SO 2 ;  
 R 1  is an optionally substituted alkyl, alkenyl, alkynyl, alkoxy, carboxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halogen, —COR 8 , where R 8  is H, —OH, an optionally substituted alkyl, alkoxy, or —OR 6  where R 6  is hydrogen or an optionally substituted alkyl; and  
 A is N, C, CH or CH 2 .  
 
     
     
         2 - 24 . (canceled)

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