Novel method of diagnosing, monitoring, staging, imaging and treating various cancers

Abstract

The present invention provides a new method for detecting, diagnosing, monitoring, staging, prognosticating, imaging and treating selected cancers including gynecologic cancers such as breast, ovarian, uterine and endometrial cancer and lung cancer.

1 . A method for detecting the presence of a selected cancer in a patient comprising: 
 (a) measuring levels of CSG in cells, tissues or bodily fluids in a patient; and    (b) comparing the measured levels of CSG with levels of CSG in cells, tissues or bodily fluids from a normal human control, wherein a change in measured levels of CSG in said patient versus normal human control is associated with the presence of a selected cancer.    
     
     
         2 - 5 . (canceled)  
     
     
         6 . The method of  claim 1  wherein the CSG comprises SEQ ID NO:1, 10, 11, 12 or 13 and the selected cancer is a gynecologic cancer selected from the group consisting of breast, ovarian, endometrial and uterine cancer.  
     
     
         7 . The method of  claim 1  wherein the CSG comprises SEQ ID NO:2, 9 or 14 and the selected cancer is lung cancer or a gynecologic cancer selected from the group consisting of ovarian, endometrial and uterine cancer.  
     
     
         8 . The method of  claim 1  wherein the CSG comprises SEQ ID NO:1, 2, 3, 9, 10, 11, 12, 13 or 14 and the selected cancer is ovarian cancer.  
     
     
         9 . An antibody against a CSG wherein said CSG comprises SEQ ID NO:1, 2, 3, 9, 10, 11, 12, 13 or 14.  
     
     
         10 . A method of imaging or treating a selected cancer in a patient comprising administering to the patient an antibody of  claim 9 .  
     
     
         11 . The method of  claim 10  wherein said antibody is labeled with paramagnetic ions or a radioisotope.  
     
     
         12 . (canceled)  
     
     
         13 . The method of  claim 10  wherein the antibody is conjugated to a cytotoxic agent.