Methods for treating joint inflammation

Abstract

This invention provides methods and formulations for treating an inflammatory disease or reducing an inflammatory reaction comprising administering a fortified formulation comprising stabilized rice bran derivative and a fortification agent. Preferred rice bran derivatives are rice bran oil and the solubilized fraction of rice bran. Preferred fortification agents are glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract.

1 . A method for treating an inflammatory disease or reducing an inflammatory reaction in a mammal, said method comprising: 
 administering a fortified formulation comprising a stabilized rice bran derivative and at least one fortification agent, thereby treating an inflammatory disease or reducing an inflammatory reaction in said mammal.    
     
     
         2 . The method of  claim 1 , wherein said stabilized rice bran derivative is a member selected from the group consisting of rice bran oil, enzyme-treated stabilized rice bran, a solubilized fraction, and mixtures thereof.  
     
     
         3 . The method of  claim 1 , wherein said fortification agent is a member selected from the group consisting of a glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract.  
     
     
         4 . The method of  claim 1 , wherein said administering comprises ingestion of said fortified formulation.  
     
     
         5 . The method of  claim 1 , wherein said inflammatory disease is a disorder of a bone joint.  
     
     
         6 . The method of  claim 1 , wherein said inflammatory disease is a member selected from the group consisting of osteoarthritis, osteoporosis, rheumatoid arthritis, and soft tissue rheumatism.  
     
     
         7 . The method of  claim 1 , wherein said mammal is a human.  
     
     
         8 . The method of  claim 1 , wherein said mammal is an animal.  
     
     
         9 . The method of  claim 8 , wherein said animal is a member selected from the group consisting of a horse, a cat, and a dog.  
     
     
         10 . The method of  claim 1 , wherein said formulation is ingested in the amount of about 2 grams to about 100 grams per day total.  
     
     
         11 . The method of  claim 1 , wherein said formulation is a member selected from the group consisting of a cream, a capsule, a bar, a powder, a food, a food supplement, a medical food, a liquid, a beverage, an emulsion or mixture thereof.  
     
     
         12 . A method for treating lameness or loss of mobility in a mammal, said method comprising: 
 administering a fortified formulation comprising a stabilized rice bran derivative and at least one fortification agent, thereby treating lameness or increasing joint mobility.    
     
     
         13 . (canceled)  
     
     
         14 . The method of  claim 12 , wherein said fortification agent is a member selected from the group consisting of a glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract.  
     
     
         15 - 20 . (canceled)  
     
     
         21 . A method for reducing pain in or around a bone joint in a mammal, said method comprising: 
 administering a fortified formulation comprising a stabilized rice bran derivative and at least one fortification agent, thereby reducing pain in or around said bone joint.    
     
     
         22 . The method of  claim 21 , wherein said stabilized rice bran derivative is a member selected from the group consisting of rice bran oil, enzyme-treated stabilized rice bran, a solubilized fraction, and mixtures thereof.  
     
     
         23 . The method of  claim 21 , wherein said fortification agent is a member selected from the group consisting of a glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract.  
     
     
         24 . The method of  claim 21 , wherein said administering comprises ingestion of said fortified formulation.  
     
     
         25 . The method of  claim 21 , wherein said mammal is a human.  
     
     
         26 . The method of  claim 21 , wherein said mammal is an animal.  
     
     
         27 . The method of  claim 26 , wherein said animal is a member selected from the group consisting of a horse, a cat, and a dog.  
     
     
         28 . The method of  claim 21 , wherein said formulation is ingested in the amount of about 2 grams to about 100 grams per day total.  
     
     
         29 . The method of  claim 21 , wherein said formulation is a member selected from the group consisting of a cream, a capsule, a bar, a powder, a food, a food supplement, a medical food, a liquid, a beverage, an emulsion or mixture thereof.  
     
     
         30 . A method for inhibiting prostaglandin synthetase activity, said method comprising: 
 administering a fortified formulation comprising a stabilized rice bran derivative and at least one fortification agent, thereby inhibiting prostaglandin synthetase activity.    
     
     
         31 . (canceled)  
     
     
         32 . The method of  claim 30 , wherein said fortification agent is a member selected from the group consisting of a glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract.  
     
     
         33 - 35 . (canceled)  
     
     
         36 . A fortified formulation for treating joint inflammation and loss of mobility, said formulation comprising a stabilized rice bran derivative and at least one fortification agent.  
     
     
         37 . The formulation of  claim 36 , wherein said stabilized rice bran derivative is a member selected from the group consisting of rice bran oil, enzyme-treated stabilized rice bran, a solubilized fraction, and mixtures thereof.  
     
     
         38 . The formulation of  claim 36 , wherein said fortification agent is a member selected from the group consisting of a glucosamine derivative, methylsulfonylmethane, yucca concentrate, and grape seed extract.  
     
     
         39 . The formulation of  claim 36 , wherein said formulation is a powder.  
     
     
         40 . The formulation of  claim 36 , wherein said formulation is a liquid.  
     
     
         41 . A method for treating an inflammatory disease or reducing an inflammatory reaction in a mammal, said method comprising: administering a tocol composition, thereby treating an inflammatory disease or reducing an inflammatory reaction in a mammal.  
     
     
         42 . A method for treating lameness or loss of mobility, said method comprising: administering a tocol composition, thereby treating lameness or loss of mobility.  
     
     
         43 . A method for inhibiting prostaglandin synthetase activity, said method comprising: administering a tocol composition, thereby inhibiting prostaglandin synthetase activity.  
     
     
         44 . A formulation for treating joint inflammation and loss of mobility, said formulation comprising a tocol composition.  
     
     
         45 . The formulation of  claim 44 , wherein said formulation is a cream.  
     
     
         46 . A method for treating an inflammatory disease or reducing an inflammatory reaction in a mammal, said method comprising: 
 administering a stabilized rice bran derivative thereby treating an inflammatory disease or reducing an inflammatory reaction in said mammal.    
     
     
         47 . The method of  claim 46 , wherein said stabilized rice bran derivative is a member selected from the group consisting of rice bran oil, enzyme-treated stabilized rice bran, a solubilized fraction, and mixtures thereof.