High concentration dinotefuran formulations containing methoprene

Abstract

A topical insecticide is provided which can be safe to use and avoids many common deleterious side effects of conventional topical insecticides. In one preferred embodiment of the invention, the active ingredient of the insecticide formulation is an amine derivative, having a nitro-methylene group, a nitroamino group or a cyanoamino group, which can be formulated to have low toxicity and excellent insecticidal activity. One particularly suitable insecticide is 1-{(tetrahydro-3-furanyl)methyl}-2-nitro-3-methylguanidine (dinotefuran), an aldulticide that will kill adult fleas combined with methoprene.

1 . An insecticide formulated by dissolving an insecticidably effective amount of an insecticidal (tetrahydro-3-furanyl)methylamine derivative in an effective amount of a solvent component, said solvent component comprising sufficient methoprene to increase the solvency of the insecticidal derivative in the solvent component compared to the solvency of the insecticidal derivative in the solvent component without the methoprene and to increase the effectiveness of the insecticide compared to its effectiveness without the methoprene.  
     
     
         2 . The insecticide of  claim 1 , wherein said insecticidal derivative is dinotefuran.  
     
     
         3 . The insecticide of  claim 2 , wherein said solvent component comprises phenyl methanol.  
     
     
         4 . The insecticide of  claim 1 , wherein said insecticidal derivative is dissolved in the formulation to a concentration of about 5 to 25%.  
     
     
         5 . The insecticide of  claim 3 , wherein said insecticidal derivative is dissolved in the formulation to a concentration of about 9 to 20%.  
     
     
         6 . The insecticide of  claim 5 , comprising over 0.1% methoprene.  
     
     
         7 . The insecticide of  claim 5 , comprising about 0.1 to 3% methoprene.  
     
     
         8 . The insecticide of  claim 1 , wherein the formulation is not irritating to dogs or cats and is effective to kill fleas with applications of less than 20 ml to a cat.  
     
     
         9 . The insecticide of  claim 2 , wherein the formulation is not irritating to dogs or cats and is effective to kill fleas with applications of less than 20 ml to a cat.  
     
     
         10 . The insecticide of  claim 3 , wherein the formulation is not irritating to dogs or cats and is effective to kill fleas with applications of less than 20 ml to a cat.  
     
     
         11 . The insecticide of  claim 1 , wherein one drop of the formulation is effective to kill fleas on a cat for at least one month.  
     
     
         12 . The insecticide of  claim 2 , wherein one drop of the formulation is effective to kill fleas on a cat for at least one month.  
     
     
         13 . The insecticide of  claim 3 , wherein one drop of the formulation is effective to kill fleas on a cat for at least one month.  
     
     
         14 . A method of controlling insect infestation in animals, comprising dissolving dinotefuran in a solvent mixture comprising methoprene and applying an insecticidably effective amount of the solution to an animal.  
     
     
         15 . The method of  claim 14 , wherein the animal is a cat or a dog.  
     
     
         16 . The method of  claim 15 , wherein the insect is a flea.  
     
     
         17 . A method of preparing an insecticide, comprising dissolving an insecticide in a composition comprising methoprene, wherein at least a portion of the insecticide is dissolved by the methoprene.