US2005175657A1PendingUtilityA1

Medical implants and fibrosis-inducing agents

59
Assignee: ANGIOTECH INT AGPriority: Nov 10, 2003Filed: Dec 2, 2004Published: Aug 11, 2005
Est. expiryNov 10, 2023(expired)· nominal 20-yr term from priority
Inventors:William L. HunterDavid GravettPhilip M. ToleikisArpita MaitiPierre SignoreRichard Liggins
A61P 9/00A61P 43/00A61B 17/12022A61L 2300/412A61L 31/16A61K 38/39A61L 2300/00A61B 17/12168A61P 1/00A61B 17/1219A61L 27/54A61F 2250/0067A61B 17/12099A61K 38/38A61K 38/4833A61B 17/12109A61B 17/68A61B 17/1214A61K 38/363A61K 45/06A61B 17/12186A61L 2430/38A61P 19/00A61B 17/11
59
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Claims

Abstract

Implants are used in combination with a fibrosis-inducing agent in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or increase fibrosis between the implant and the host tissue.

Claims

exact text as granted — not AI-modified
1 - 91 . (canceled)  
     
     
         92 . An injectable composition comprising a fibrosing agent and a bulking agent.  
     
     
         93 . (canceled)  
     
     
         94 . The composition of  claim 92  wherein the fibrosing agent promotes angiogenesis.  
     
     
         95 . The composition of  claim 92  wherein the fibrosing agent promotes fibroblast migration.  
     
     
         96 . The composition of  claim 92  wherein the fibrosing agent promotes fibroblast proliferation.  
     
     
         97 . The composition of  claim 92  wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).  
     
     
         98 . The composition of  claim 92  wherein the fibrosing agent promotes tissue remodeling.  
     
     
         99 . The composition of  claim 92  wherein the fibrosing agent is an arterial vessel wall irritant.  
     
     
         100 . The composition of  claim 92  wherein the fibrosing agent is or comprises silk.  
     
     
         101 . The composition of  claim 92  wherein the fibrosing agent is or comprises silkworm silk.  
     
     
         102 . The composition of  claim 92  wherein the fibrosing agent is or comprises spider silk.  
     
     
         103 . The composition of  claim 92  wherein the fibrosing agent is or comprises recombinant silk.  
     
     
         104 . The composition of  claim 92  wherein the fibrosing agent is or comprises raw silk.  
     
     
         105 . The composition of  claim 92  wherein the fibrosing agent is or comprises hydrolyzed silk.  
     
     
         106 . The composition of  claim 92  wherein the fibrosing agent is or comprises acid-treated silk.  
     
     
         107 . The composition of  claim 92  wherein the fibrosing agent is or comprises acylated silk.  
     
     
         108 - 111 . (canceled)  
     
     
         112 . The composition of  claim 92  wherein the fibrosing agent is or comprises talc.  
     
     
         113 . The composition of  claim 92  wherein the fibrosing agent is or comprises chitosan.  
     
     
         114 . The composition of  claim 92  wherein the fibrosing agent is or comprises polylysine.  
     
     
         115 . The composition of  claim 92  wherein the fibrosing agent is or comprises fibronectin.  
     
     
         116 . The composition of  claim 92  wherein the fibrosing agent is or comprises bleomycin.  
     
     
         117 . The composition of  claim 92  wherein the fibrosing agent is or comprises CTGF.  
     
     
         118 - 7412 . (canceled)  
     
     
         7413 . A method of making an injectable composition comprising combining a fibrosing agent and a bulking agent.  
     
     
         7414 . (canceled)  
     
     
         7415 . The method of  claim 7413  wherein the fibrosing agent promotes angiogenesis.  
     
     
         7416 . The method of  claim 7413  wherein the fibrosing agent promotes fibroblast migration.  
     
     
         7417 . The method of  claim 7413  wherein the fibrosing agent promotes fibroblast proliferation.  
     
     
         7418 . The method of  claim 7413  wherein the fibrosing agent promotes deposition of extracellular matrix (ECM).  
     
     
         7419 . The method of  claim 7413  wherein the fibrosing agent promotes tissue remodeling.  
     
     
         7420 . The method of  claim 7413  wherein the fibrosing agent is or comprises an arterial vessel wall irritant.  
     
     
         7421 . The method of  claim 7413  wherein the fibrosing agent is or comprises silk.  
     
     
         7422 . The method of  claim 7413  wherein the fibrosing agent is or comprises silkworm silk.  
     
     
         7423 . The method of  claim 7413  wherein the fibrosing agent is or comprises spider silk.  
     
     
         7424 . The method of  claim 7413  wherein the fibrosing agent is or comprises recombinant silk.  
     
     
         7425 . The method of  claim 7413  wherein the fibrosing agent is or comprises raw silk.  
     
     
         7426 . The method of  claim 7413  wherein the fibrosing agent is or comprises hydrolyzed silk.  
     
     
         7427 . The method of  claim 7413  wherein the fibrosing agent is or comprises acid-treated silk.  
     
     
         7428 . The method of  claim 7413  wherein the fibrosing agent is or comprises acylated silk.  
     
     
         7429 - 7432 . (canceled)  
     
     
         7433 . The method of  claim 7413  wherein the fibrosing agent is or comprises talc.  
     
     
         7434 . The method of  claim 7413  wherein the fibrosing agent is or comprises chitosan.  
     
     
         7435 . The method of  claim 7413  wherein the fibrosing agent is or comprises polylysine.  
     
     
         7436 . The method of  claim 7413  wherein the fibrosing agent is or comprises fibronectin.  
     
     
         7437 . The method of  claim 7413  wherein the fibrosing agent is or comprises bleomycin.  
     
     
         7438 . The method of  claim 7413  wherein the fibrosing agent is or comprises CTGF.  
     
     
         7439 - 10247 . (canceled)

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