Antiinfective free intramammary veterinary composition

Abstract

An antiinfective-free formulation for prophylactic traetment of mastitis in dry cows comprises a seal formulation having approximately 65% by weight of bismuth sub-nitrate in a gel based on aluminium stearate. The seal formulation is prepared by adding the bismuth sub-nitrate to the gel base in at least two separate stages.

1 - 40 . (canceled)  
     
     
         41 . An antiinfective-free method of prophylactic treatment of mammary disorders in non-human animals during an animal's dry period by sealing the teat canal with a seal formulation to provide a physical barrier in the teat canal, wherein the seal formulation comprises a non-toxic heavy metal salt in a gel base, and wherein no antiinfective agent is introduced into said teat canal during said animal's dry period.  
     
     
         42 . A prophylactic method of controlling infection of the mammary gland by a mastitis-causing organism comprising sealing the gland with a seal formulation to provide a physical barrier in the teat canal, wherein the seal formulation comprises a non-toxic heavy metal salt in a gel base and wherein no antiinfective agent is introduced into said teat canal during said animal's dry period.  
     
     
         43 . (canceled)  
     
     
         44 . (canceled)  
     
     
         45 . A method as claimed in  claim 41  wherein the seal formulation contains at least 40% by weight of the heavy metal salt.  
     
     
         46 . A method as claimed in  claim 42  wherein the seal formulation contains at least 40% by weight of the heavy metal salt.  
     
     
         47 . A method as claimed in  claim 41  wherein the seal formulation contains from 50% to 75% by weight of the heavy metal salt.  
     
     
         48 . A method as claimed in  claim 42  wherein the seal formulation contains from 50% to 75% by weight of the heavy metal salt.  
     
     
         49 . A method as claimed in  claim 41  wherein the seal formulation contains approximately 65% by weight of the heavy metal salt.  
     
     
         50 . A method as claimed in  claim 42  wherein the seal formulation contains approximately 65% by weight of the heavy metal salt.  
     
     
         51 . A method as claimed in  claim 41  wherein the salt is bismuth sub-nitrate, the base is a gel based on aluminium stearate and the base includes liquid paraffin as a vehicle.  
     
     
         52 . A method as claimed in  claim 42  wherein the salt is bismuth sub-nitrate, the base is a gel based on aluminium stearate and the base includes liquid paraffin as a vehicle.  
     
     
         53 . A process for preparing a seal formulation comprising the steps of adding a non-toxic heavy metal salt to a gel base in at least two separate stages, wherein a first portion of heavy metal salt is added to a gel base in a first stage and a second portion of the heavy metal salt is added to a gel base containing the first portion of the heavy metal salt.  
     
     
         54 . A process as claimed in  claim 53  wherein the weight ratio of the second portion of the heavy metal salt to the first portion of the heavy metal salt is at least 1:1 and approximately 2:1.  
     
     
         55 . A process as claimed in  claim 53  wherein the seal formulation contains at least 40% by weight of the heavy metal salt.  
     
     
         56 . A process as claimed in  claim 53  wherein the seal formulation contains from 50% to 75% by weight of the heavy metal salt.  
     
     
         57 . A process as claimed in  claim 53  wherein the seal formulation contains approximately 65% by weight of the heavy metal salt.  
     
     
         58 . A process as claimed in  claim 53  wherein the salt is bismuth sub-nitrate, the base is a gel based on aluminium stearate, and the gel contains liquid paraffin as a vehicle.  
     
     
         59 . The method of  claim 41  wherein said antiinfective agent is an antibiotic.  
     
     
         60 . The method of  claim 42  wherein said antiinfective agent is an antibiotic.