Adhesive-containing wound closure device and method

Abstract

A tissue bonding article includes a flexible material, an adhesive substance applied over at least a portion of a bottom side of the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material.

1 . A tissue bonding article, comprising: 
 a flexible material;    an adhesive substance applied over at least a portion of a bottom side of said flexible material; and    a polymerizable adhesive composition permeated throughout at least a portion of said flexible material.    
     
     
         2 . The article of  claim 1 , wherein said flexible material is a mesh.  
     
     
         3 . The article of  claim 1 , wherein said flexible material comprises perforations or tear lines.  
     
     
         4 . The article of  claim 1 , wherein said flexible material is flexible and porous.  
     
     
         5 . The article of  claim 1 , wherein said flexible material is substantially free of elastin.  
     
     
         6 . The article of  claim 1 , wherein said flexible material is elastic.  
     
     
         7 . The article of  claim 1 , wherein said adhesive substance is applied over a first and a second portion of said flexible material.  
     
     
         8 . The article of  claim 7 , wherein said first and second portions are located substantially at opposite ends of said flexible material.  
     
     
         9 . The article of  claim 7 , wherein said first and second portions do not cover an entire surface area of said flexible material.  
     
     
         10 . The article of  claim 7 , wherein said flexible material comprises perforations or tear lines proximate to said first and second portions.  
     
     
         11 . The article of  claim 1 , wherein said adhesive substance is a pressure sensitive adhesive.  
     
     
         12 . The article of  claim 11 , wherein said pressure sensitive adhesive has a weaker bonding strength than said polymerizable adhesive composition.  
     
     
         13 . The article of  claim 1 , wherein said adhesive substance does not interact with said polymerizable adhesive composition.  
     
     
         14 . The article of  claim 1 , wherein said polymerizable adhesive composition is a monomeric composition.  
     
     
         15 . The article of  claim 1 , wherein said polymerizable adhesive composition is polymerized.  
     
     
         16 . The article of  claim 1 , wherein said polymerizable adhesive composition comprises a 1,1-disubstituted monomer.  
     
     
         17 . The article of  claim 1 , wherein said polymerizable adhesive composition comprises a cyanoacrylate monomer.  
     
     
         18 . The article of  claim 1 , wherein said polymerizable adhesive composition, after polymerization, substantially covers surfaces on at least said bottom side and a top side of said flexible material.  
     
     
         19 . The article of  claim 18 , wherein said polymerizable adhesive composition, after polymerization, substantially does not cover said adhesive substance.  
     
     
         20 . The article of  claim 1 , further comprising a polymerization initiator or rate modifier for said polymerizable adhesive composition disposed in or on said flexible material.  
     
     
         21 . The article of  claim 20 , wherein said polymerization initiator or rate modifier is immobilized on said flexible material.  
     
     
         22 . The article of  claim 1 , further comprising a bioactive material disposed in or on said flexible material.  
     
     
         23 . The article of  claim 22 , wherein said bioactive material is not immobilized on said flexible material, but is soluble or dispersible in said polymerizable adhesive composition.  
     
     
         24 . The article of  claim 1 , wherein the flexible material is biodegradable.  
     
     
         25 . The article of  claim 1 , wherein the flexible material is not biodegradable.  
     
     
         26 . The article of  claim 1 , wherein the flexible material and the polymerizable adhesive composition are together biodegradable.  
     
     
         27 . The article of  claim 1 , wherein the flexible material and the polymerizable adhesive composition are together not biodegradable.  
     
     
         28 . The article of  claim 1 , wherein the article is opaque.  
     
     
         29 . The article of  claim 1 , wherein the article is translucent.  
     
     
         30 . The article of  claim 1 , wherein said adhesive substance is applied over substantially the entire bottom side of said flexible material.  
     
     
         31 . The article of  claim 30 , wherein said adhesive substance is permeated by said polymerizable adhesive composition.  
     
     
         32 . The article of  claim 30 , wherein said flexible substrate not include features that penetrate an underlying substrate during use.  
     
     
         33 . The article of  claim 1 , further comprising one or more adhesive strips attached to the flexible material, wherein the adhesive substance is provided on the one or more adhesive strips.  
     
     
         34 . A method of bonding tissue, comprising: 
 placing a flexible substrate over a section of tissue, wherein said flexible substrate comprises a flexible material and an adhesive substance applied over at least a portion of a bottom side of said flexible material;    applying a polymerizable adhesive composition over and substantially covering at least a portion of the flexible substrate; and    allowing the polymerizable adhesive composition to permeate into and under the flexible substrate and polymerize to form a composite structure bonded to said tissue.    
     
     
         35 . The method of  claim 34 , wherein said section of tissue includes a wound to be closed.  
     
     
         36 . The method of  claim 35 , wherein said placing comprises: 
 fixing a first portion of said flexible substrate to said section of tissue on a first side of said wound;    approximating edges of said wound; and    fixing a second portion of said flexible substrate to said section of tissue on a second of said wound opposite said first side of said wound.    
     
     
         37 . The method of  claim 36 , further comprising removing said first and second portions of said flexible substrate.  
     
     
         38 . The method of  claim 37 , wherein a third portion of said flexible substrate remains, covering said wound.  
     
     
         39 . The method of  claim 37 , wherein said removing comprises trimming said first and second portions of said flexible substrate.  
     
     
         40 . The method of  claim 35 , wherein said placing comprises: 
 fixing a first lengthwise end of said flexible substrate to said section of tissue on a first lengthwise end of said wound;    approximating edges of said wound; and    fixing a second lengthwise end of said flexible substrate to said section of tissue on a second lengthwise end of said wound opposite said first lengthwise end of said wound.    
     
     
         41 . The method of  claim 35 , wherein said applying comprises: 
 placing a quantity of said polymerizable adhesive composition on an exposed side of the flexible substrate; and    spreading the quantity of polymerizable adhesive composition to substantially cover the flexible substrate.    
     
     
         42 . The method of  claim 35 , wherein: 
 said section of tissue has a length and a width, said length being longer than said width;    said wound has a length and a width, said length being longer than said width;    and said wound extends lengthwise in a lengthwise direction of said section of tissue.    
     
     
         43 . The article of  claim 1 , wherein the flexible material is sterilized.  
     
     
         44 . The article of  claim 1 , wherein the polymerizable adhesive composition is sterilized.